Archives

A Novel Strategy for Communication to Drive Voluntary Compliance with Social Distancing in COVID-19 across Religious-Cultures in Mumbai India – The Case of ‘Cognitive Polyphasia’

DOI: 10.31038/JIPC.2022212

Abstract

Aims: Social distancing contains the coronavirus but compliance with social distancing is challenging. Previous studies called to enhance compliance by culturally adaptive messages. We fill the gap in the state of the art testing the power of specific messages as drivers of willingness to comply.

Methods: The sample comprised 277 residents of Mumbai India, who self-classified themselves into one of four religious-cultural groups. A conjoint-based experimental-design was applied with willingness to comply as the dependent variable and contributors to compliance as independent variables.

Results: Regression coefficients for the total panel suggested minor differences in the power of messages. Commonalities in response patterns yielded three distinct mindsets transcending cultures: people seeking to assure compliance; people focusing on the policy communicator; and people focusing on risks of coronavirus. Different messages drive willingness to comply among members of each mindset.

Conclusions: A web-based prediction tool enables to identify the mindset-belonging of individuals/groups and use mindset-tailored messaging to enhance compliance.

Keywords

COVID-19; India; Messaging; Mindset-segments; Religious-culture; Social distancing; Social representation theory; Voluntary compliance

Introduction

Under the complexity and uncertainty of the COVID-19 pandemic, social distancing was found to be effective in containing the Coronavirus [1,2]. Social distancing entails isolation of people with symptoms of COVID-19; quarantines for people with confirmed COVID-19; prohibition congregations, and maintaining physical distance. Social distancing is a central non-pharmaceutical intervention for breaking the chain of infection transmission [3-6]. But compliance with social distancing is poor among members from different cultures compared to the general population [7,8]. Health authorities aspire to optimize compliance with social distancing [9,10]. Optimal compliance with social distancing emerges from personal responsibility for the greater good [11].

In India the COVID-19 pandemic started on 30 January 2020. Within 8 months, India reported 78,761 new cases; 3,542,733 cumulative cases; and 63,498 cumulative deaths on 30 August 2020 [12,13]. Health authorities in India were early to adopt non-pharmaceutical interventions to contain the spread of the Coronavirus slowing the spread of the epidemic [14]. The government of India implemented sought to  understand the impact of social distancing interventions on the dynamics of the daily rates of COVID-19 infections, by estimating rates across 7 periods of the pandemic (Pre-lockdown, Lockdown Phases 1 to 4 and Unlock 1–2), and phased relaxations [1]. Interventions were estimated using Google mobility data, estimates at the national level and for 12 Indian states [1].

Data collection in this current study was from May 20 to July 28th, 2020, which was parallel to the third and fourth strict Lockdown from May 18th to May 31st and to the first and second unlock phases from 1 June to 31 July 2020 in which a conditional relaxation was allowed where the virus spread was contained. A study performed in April 2020 with 2164 participants from India through social networks and WhatsApp found that 61% of participants had heard details about COVID‑19 from the social media, 89% knew all ways of coronavirus transmission, 40% felt that COVID‑19 is a serious disease, and 78% agreed with the lockdown intervention, 85% believed that lockdowns help reduce the rate of infection, 89% reported following lockdown guidelines, and 87% reported maintaining social distancing [15]. Data, however, indicated that knowledge about the virus and positive attitudes towards social distancing did not enhance compliance with it [1]. In Mumbai as well, poor compliance with social distancing was evident resulting in a severe outbreak of COVID-19 [10,16,17].

Social distancing is challenging as it alters norms (e.g., personal space, transportation, gender relations within the family), particularly in heavily populated crowded living conditions as in Mumbai [3,18]. Health authorities acknowledge that communication is essential to voluntary compliance [3,8]. People may comply better with social distancing if messages are crafted to promote voluntary rather than mandatory compliance [2,19]. To protect the vulnerable population, in the absence of an effective treatment and a vaccine, social distancing will continue as the non-pharmaceutical intervention, especially in a populous crowded country as India [14,20].

Health authorities have a critical role in designing messages clearly and consistently to enhance willingness to comply (hereafter: WTC) with social distancing [7,21-23]. Culture was found to be central designing messages to shape behavior [24]. The social representation theory stresses that messages regarding social distancing need to be adapted to religious cultures so they reflect the shared reality of group members of each religious culture yielding higher WTC [24-26]. Health authorities were called upon to consider the unique characteristics, needs, and behaviors, of members of distinct religious cultures in designing messages to contain the spread of the virus. Since WTC is strongly related to compliance behavior, identifying messages that drive WTC with social distancing is essential to higher WTC across religious cultures [2,27,28]. Research on the effect of specific messaging on WTC with social distancing in the COVID-19 context is scant. This study responds to previous calls to discover messages that influence WTC particularly necessary for those whose compliance with preventive measures is lower [1,2,24,29-31]. This study seeks to start closing the gaps in state-of-the-art by applying novel strategy for communication to enhance WTC with social distancing.

This study tests the power of messages as drivers of WTC with social distancing From May 18th 2020 to July 31st, 2020 across religious cultures in Mumbai, India [32]. Perceived benefits of social distancing and its practices predict WTC with social distancing [23]. Likewise, trust in the agent communicating the social distancing policy enhances compliance [33]. Some messages may have greater power in driving WTC. Membership in a religious culture relates to shared history, myths, beliefs, language, values, which may not be a matter of personal choice but rather be shared by all members of that religious culture [25].

According to the social representation theory, one’s inner world encompasses both the collective and the personal, creating a shared reality among members of a religious-cultural group [25]. The shared religious-culture may transcend the individual so that one’s identity accords with perceptions, beliefs, and norms of the religious-cultural group, ignoring dimensions that are inconsistent with them [34]. The influence of messages on WTC with social distancing may depend, in part, on how people from different religious cultures identify with the different messages [35]. Individuals may differ from each other in many other ways but will share a common response to the messaging on social distancing.

Hypothesis 1: Groups of People Will Respond Similarly to Different Messages on Social Distancing, by Their Religious-Cultural Belonging, Revealing ‘Cultural-Mindsets’

In a pandemic, individuals may have low exposure to mass communication and to networks, they may lack information, or may have different individual experiences (e.g., being infected, quarantined, or hospitalized), all creating a different psychological impact [36]. It is therefore possible that messages regarding social distancing may center the individual, transcending cultural differences.

Hypothesis 2: Groups of People Will have Similar Response Patterns to Different Messages Regarding Social Distancing, Transcending Religious-Cultural Belonging

We explore the effectiveness of messages to drive WTC with social distancing across religious-cultural groups in Mumbai, India. The exploratory research questions are a). Do responses to messaging differ by religious-cultural group? b). What patterns of response are there to different messages?

Subjects and Methods

Ethics

This study is part of a multi-national research project on WTC with social distancing during the second wave of COVID-19 in Canada, the US, Hungary, Italy, Turkey, England, Australia, India, and Israel. This study protocol was approved by the Ryerson University Research Ethics Board (#2020-149). Participants were informed that participation is anonymous and confidential. Participants signed an informed consent regarding participation and publication.

Sample

Respondents were 277 residents of various neighborhoods of Mumbai. Respondents were recruited through social networks and were not paid for their participation. The sample size is acceptable for conjoint-based studies, particularly when aiming for stable coefficients [37]. Based on the concept of religiousness as a universal four-dimensional structure which was recently validated as encompassing the four dimensions of religiousness for cross-cultural and cross-religious research applications in India, participants self-classified themselves to one of the four groups: believing (orthodox), bonding (conservative), behaving (liberal), and not belonging (no religion) [16,38].

Procedure

We utilized an experimental design in which we allocated participants to different groups using repeated measures, where the same participants took part in each condition of each of the independent variables (within groups, or within-subjects design). In this experimental design, participants rated a series of different combinations of messages with the same rating question. This way, participants did not complete “parallel measures” but were repeatedly exposed to the same question in relation to different aspects of physical distancing. To control the results, we alternated the order by which participants performed in different conditions of an experiment. This experimental design enabled higher variation, randomization, analysis of co-variance and control than in typical observational studies [39]. Considering our complex reality, in which many stimuli may interact with one another, we utilized well known conjoint-based experimental design methodology known for testing the power of messages which has been used to test the power of messages in a great variety of topics [40,41]. With 277 participants and 16 messages in 24 vignettes presented to each participant, 4432 messages were tested with no limitation of degrees of freedom while bypassing typical biases of surveys [37]. A digital link for this online study was distributed through social networks and snowball sampling.

Instrument

The dependent variable is ‘WTC with social distancing, independent variables in conjoint analysis are four categories, each acknowledged as a driver of WTC with social distancing [23,33]. Each category contained four messages, strictly one from each category, all together sixteen different messages. Messages were created based on elements we identified in a thorough literature review on drivers of compliance with social distancing [41]. Participants were instructed to rate each vignette as a unity [37]. The rating question was: “To what extent does the following vignetter drive your WTC with social distancing?” The rating question appeared on each screen above the vignette. The rating scale ranged on a scale of 1 (Does not at all drive my WTC with social distancing) to 9 (Strongly drives my WTC with social distancing).

The order of the vignettes was dictated by a well-crafted mathematical method called an ‘experimental design’ which structures the 24 vignettes to ensure statistical independence of the predictor variables for subsequent regression at both the individual and group levels [26,29] The vignettes generated a compound message, pulling in different directions, forcing the respondents to evaluate the vignette using their intuition reducing typical biases of surveys [29]. Instrument reliability was tested by comparing data for the total sample with data for half of the sample (0.70; 0.76). Table 1 presents the study instrument.

Table 1: The Instrument with Messages according to the Four Independent Variables

Code Message
Category A: The perceived risk of the COVID-19
A1 The COVID-19 is a dangerous virus spreading wildly.
A2 Health experts suggest what to do, but government is reactive rather than proactive.
A3 The COVID-19 is not a dangerous virus, but the media dramatizes its strain.
A4 Experts suggest what to do, but the government is reactive rather than proactive
Category B: Preferences of social distancing practices
B1 To practice social distancing, everyone should work only from home on internet, e.g., Zoom/Skype
B2 To practice social distancing, everyone stays 2 meters apart.
B3 To practice social distancing, everyone is to be confined to within 100 meters from home.
B4 To practice social distancing, everyone should wear a mask everywhere.
Category C: Ways to ensure social distancing
C1 To assure social distancing, we need a military lockdown.
C2 To assure social distancing, food shopping should be limited to 3 people at a time and pharmacy shopping to 1 person at a time.
C3 To assure social distancing, only age 60+ are allowed to buy groceries during first 2 hours of store day.
C4 To assure social distancing, designated young volunteers should shop for elderly and disabled.
Category D: The agent communicating the social distancing policy
D1 Provincial/State Government should communicate the social distancing policy.
D2 Federal Government should communicate the social distance policy.
D3 Religious Clergy should communicate the social distancing policy.
D4 The media should communicate the social distancing policy.

Data Analysis

The experimental design enabled the deconstruction of responses to the messages by ordinary least-squares regression (OLS) [37]. We created 277 models for WTC using OLS, one for each respondent, each with an additive constant and 16 coefficients, one coefficient for each message. The additive constant is the intercept in a linear equation that may be interpreted as the predisposition of the group to agree to a set of messages in the absence of any specific message. High additive constants (60+) represent groups of people who are likely to agree with the messages. Low additive constants (<35) represent groups of people for whom specific messages drive agreement, not the general proclivity to agree.

We performed OLS to generate individual level equations for each respondent relating to the presence/absence of the sixteen messages [40]. The OLS model was written as follows: for 1, where for 2 is the predicted or expected value of WTC (here, the transformed, binarized ratings), x1 through for 3 are for 4 distinct independent or predictor variables. for 5 is the value of Y when all of the independent variables, (x1 through for 3), are equal to zero, and for 6 through for 7 are the estimated regression coefficients. The OLS coefficient is the conditional probability that the specific message adds to the perceived driving power of the message for WTC. A coefficient of six or higher is statistically significant, given the standard error of about 4 for the coefficient [40]. A higher coefficient means higher WTC. OLS was run for the total panel, for each religious-culture and for key subgroups (gender, age), incorporating all relevant data into one regression model for the sample. The response to the vignettes, uncovered by OLS, reveals the part-worth contribution of each message to WTC [40].

Since the self-ratings of respondents are not calibrated, following OLS the rating was transformed to a categorical variable (1-6=0; 7-9=1) enabling reduction of variability and crystallization of the strongest drivers of WTC. Next, we analyzed response patterns to each message, using k-means clustering algorithm with 1 Pearsons’s R distance measure. Fundamental groups, ‘mindsets’, emerged. ANOVA and Post Hoc tests indicated that differences among mindsets are significant and different specific messages drive l WTC for each group. The pattern of positive high coefficients across the mindsets guided the assignment of respondents to mindsets. Last, to translate the knowledge to policy implementation, we developed a prediction tool, the personal viewpoint identifier (PVI). The PVI enables health authorities to may assign a person in the population to a mindset based on the summary data, converting the six strong distinguishing messages to binary questions (agree or disagree). The six messages were chosen using a Monte-Carlo simulation. Each of the 64 possible patterns of responses to the set of six messages is best associated with one of the three mindsets. Based on answers to the six questions in the PVI, the individual or group is assigned to one of the three mindsets, and thus, the appropriate messages may be established for individuals or groups.

Results

Preliminary Analysis

Participants were 202 Liberals, 41 conservatives, 19 orthodox, and 15 with no religion belonging, ages 18 to 70. The sample comprised 130 females and 147 males. The response rate was 48% (Out of 573 people that started the online-study, 277 completed it). Table 2 presents the sample demographics.

Table 2: Sample Demographic Composition

Variable

Level

Size (n)

Affiliation

 

 

 

Liberal

202

Conservative

41

Orthodox

19

No religion

15

Gender Female

130

Male

147

 

 

Age

18-24

53

25-34

167

35-44

33

45-54

13

55-64

9

65+

2

Hypotheses Testing

To simplify the analysis, we present only messages with positive regression coefficients, driving WTC with social distancing. There were no significant differences in the driving power of messages for the total panel and subgroups. Significant differences emerged when respondents were clustered by the commonality in the patterns of their responses to the individual messages. Analysis of variance and post hoc tests indicate that the distinct mindsets that emerged from are significantly different, highlighting the different messages that impact WTC with social distancing for members of each mindset. The pattern of positive high coefficients across different mindsets guided the assignment of respondents to a mindset. Mindsets are “Pandemic Observers”, who pay close attention to the news; “Obedient Followers”, who expect to be told EXACTLY what to do; and “Sensitive Interpreters” who are attentive to what the government decides. The names of the mindsets were determined by the dominant messages in each. Table 3 presents the additive constant, coefficients, p values, and post hoc results of the mindset-segmentation.

Table 3: Mindset segments by ANOVA and Post Hoc Tests for Messages Driving WTC

Group

Total Segment 1 of 3 Segment 2 of 3

Segment 3 of 3

Base Size

277

92 81

104

Additive Constant

52

58 49

49

Code Category A: The perceived risk of the COVID-19 virus
A1 The COVID-19 is a dangerous virus spreading wildly.

0

-12a -6a

14b

A2 The COVID-19 is not a dangerous virus, but the media over dramatizes its strain.

-1

-12a -3b

10c

A3 Health experts suggest what to do but government is reactive rather than proactive.

-2

-17a -5b

13c

A4  The COVID-19 is not dangerous, but all news seems to be about it.

-2

-15a -1b

11c

Category B: Preference of social distancing practices
B1 To practice social distancing everyone should work only from home on internet, e.g., Zoom/Skype

-3

-11a 5b

-4a

B2 To practice social distancing, everyone stays 2 meters apart.

-3

-12a 6b

-3a

B3 To practice social distancing, everyone should be confined to within 100 meters from home.

-3

-10a 6b

-3a

B4 To practice social distancing, everyone should wear a mask everywhere.

-4

-16a 8c

-2b

Category C: Ways to ensure social distancing
C1 To assure social distancing, we need a military lockdown.

3

15c -11a

3b

C2 To assure social distancing food shopping is to be limited to 3 people at a time and …pharmacy shopping to 1 person at a time

2

12c -12a

3b

C3 To assure social distancing only age 60+ are allowed to buy groceries during first 2 hours of store day

1

8c -9a

3b

C4 To assure social distancing, designated young volunteers should shop for elderly and disabled.

2

15c -12a

2b

Category D: The agent communicating the social distancing policy
D1 Provincial/State Government should communicate the social distancing policy.

0

3b 10c

-9a

D2 Federal Government should communicate the social distance policy.

-2

2b 5b

-12a

D3 Religious Clergy should communicate the social distancing policy.

0

1b 11c

-10a

D4 The media should communicate the social distancing policy.

0

2b 9c

-10a

Analysis of variance (ANOVA) showed significance differences (p<0.05) between mind-sets for all elements. Letters indicate homogenous subsets determined by Tukey test.

Translating Knowledge to Practice

The three mindsets transcend religious-culture, age, and gender as seen in Table 4. To identify the belonging of individuals in the population to a mindset-segment a PVI is required. We generated 64 patterns, mapping each of the three mindset-segments. We identified six messages that best differentiate among the mindset-segments, based on a two-point scale. Figure 1 presents the web based PVI. The link of the PVI for Mumbai is: https://www.pvi360.com/TypingToolPage.aspx?projectid=223&userid=2018

Table 4: Cross Tabulation among Mindsets

 

Total

MS1 Strong Controller MS2 Religious Attentive

MS3 Pandemic Observer

Total

277

92 81

104

Male

147

54 43

50

Female

130

38 38

54

20-29

157

52 50

55

30-49

100

33 24

43

50- 50 Plus

20

7 7

6

Orthodox

19

5 7

7

Conservative

41

18 9

14

Liberal

202

65 60 77
No religion

15

4 5

6

fig 1

Figure 1: Personal Viewpoint Identifier for Assigning Individuals to Sample Mindsets

Conclusion

This study applied a novel mindset-tailored communication strategy which tested the power of specific messages as drivers of WTC with social distancing through the second wave of the COVID-19 pandemic, across religious-culture groups in Mumbai, India. Theoretically, this study extends the knowledge suggesting that in an extreme health crisis, commonality is based on one’s thinking rather than on one’s belonging to a religious-cultural group. Methodologically, this study used a conjoint-based experimental design, overcoming typical biases of surveys, and simultaneously testing numerous messages with no limit of degrees of freedom. Practically, this study presents a novel strategic approach of specific mindset-tailored messaging to enhance WTC with social distancing during future waves of COVID-19.

Hypothesis 1, stating that people from religious-cultural groups will respond similarly to messages on social distancing was not corroborated. Findings contradict the social representation theory and indicate that members of religious-cultural groups have differential sensitivities to messages [25]. Hypothesis 2, stating that messages transcend religious-cultural belonging, was corroborated. Responses to messages transcended demographics and cultural differences. Findings may be explained by the ‘cognitive polyphasia’ phenomenon [42]. Accepted social representations regularly shared by members of a cultural group, may be challenged in a health crisis creating ‘cognitive polyphasia’, the coexistence of several incongruent social representations at both the group and the individual level, despite their inconsistency with the traditional social representation of the religious-cultural group [34]. Even within one culture, there may be different sources of information about social distancing, generating a variety of ways that people process the information and only then connect it to the social context of the culture.

Members of the four religious-cultural groups may have obtained different information because of who they are as a group (i.e., lack of information, little exposure to mass communication and to networks), and because of their individual experiences in the situation, (i.e., being infected, quarantined, or hospitalized), illustrating ‘cognitive polyphasia’ [42]. Thus, ‘cognitive polyphasia’ may account for the three mindsets emerging across religious cultures rather than within religious cultures [42]. The emergence of three mindsets revealed the strong messages for each mindset. The proper messages, by mindset, may encourage WTC with social distancing in a pandemic [2,3]. ‘Strong controllers’, (33%), are driven to WTC through messages detailing ways to assure compliance with social distancing: “A military lockdown”; and “Designated young volunteers to shop for the elderly and disabled.” ‘Strong controllers’ prefer harsher measures to assure compliance with social distancing. ‘Religion Attentive’, (29%), are driven to WTC by the agent communicating the message. They prefer that religious leaders communicate the policy. ‘Pandemic Observers’, (38%), pay close attention to the news and are influenced by messages describing the dangers of infection that affect their attitudes and behaviors.

Findings may prompt health officials in Mumbai, India to use the novel strategy of mindset-tailored communication to effectively optimize WTC with social distancing across religious-culture groups, rather than use the same messages for everyone. Recognizing the existence of mindsets and identifying them within the population will allow health officials to communicate through mindset-tailored messaging using the PVI we developed. To assign individuals to a mindset, individuals may be led to a video or a ‘landing page’ on a website creating a base line of mindset-belonging for groups and individuals [2].

Study Limitations and Future Directions

The independent variables of this study are based on recent literature, omitting variables that may not yet be acknowledged as drivers of WTC with social distancing. Also, participants may have been exposed to messaging regarding social distancing before participating in the study, perhaps influencing the rating of the vignettes. Further, the study used a convenience sample, and was conducted in English, perhaps limiting the sample to English speakers in India. Future studies may test the effect of mindset-tailored messaging on WTC with social distancing and examine the effect of previous exposure to messages, the prime effect of messaging, and their effect on WTC.

References

  1. Singh BB, Lowerison M, Lewinson RT, Vallerand IA, Deardon R, et al. (2021) Public health interventions slowed but did not halt the spread of COVID-19 in India. Transbound Emerg Dis 68: 2171-2187. [crossref]
  2. Saikia B, Tamuli RP, Sharma D (2020) Community engagement in times of COVID-19: Lessons from neo-Vaishnavite practices. Indian J. Med. Res 151: 499-500. [crossref]
  3. Bhatia R (2020) Public engagement is key for containing COVID-19 pandemic. Indian J Med Res 151(2 & 3): 118-120. [crossref]
  4. Kant R, Zaman K, Shankar P, Yadav R (2020) A preliminary study on contact tracing & transmission chain in a cluster of 17 cases of severe acute respiratory syndrome coronavirus 2 infection in Basti, Uttar Pradesh, India. Indian J Med Res 152(1 & 2): 95-99. [crossref]
  5. Bassi A, Arfin S, John O, Jha V (2020) An overview of mobile applications (apps) to support the coronavirus disease 2019 response in India. Indian J Med Res 151: 468-473. [crossref]
  6. Varghese GM, John R (2020) COVID-19 in India: Moving from containment to mitigation. Indian J Med Res 151: 136-139. [crossref]
  7. Andersen M (2020) Early Evidence on Social Distancing in Response to COVID-19 in the United States. SSRN [Internet] 2020
  8. Mæland S, Bjørknes R, Lehmann S, Sandal GM, Hazell W, et al. (2022) How the Norwegian population was affected by non-pharmaceutical interventions during the first six weeks of the COVID-19 lockdown. Scand J Public Health 50: 94-101. [crossref]
  9. Lytras T, Tsiodras S (2020) Lockdowns and the COVID-19 pandemic: What is the endgame? Scand J Public Health 49: 37-40. [crossref]
  10. Agrawal M, Kanitkar M, Vidyasagar M (2021) Modelling the spread of SARS-CoV-2 pandemic – Impact of lockdowns & interventions. Indian J Med Res 153: 175-181. [crossref]
  11. Collatuzzo G, Boffetta P (2021) Memorial in honour of Andrea Farioli. J. Public Health 49: 123. [crossref]
  12. Coronavirus disease 2019 (COVID-19) (2020) Situation Reports [Internet].
  13. Coronavirus Disease (COVID-19) Dashboard [Internet]
  14. Patel P, Athotra A, Vaisakh TP, Dikid T, Jain SK (2020) Impact of nonpharmacological interventions on COVID-19 transmission dynamics in India. Indian J Public Health 64: S142-S146. [crossref]
  15. Dkhar S, Quansar R, Saleem S, Khan S (202) Knowledge, attitude, and practices related to COVID-19 pandemic among social media users in J&K, India. Indian J Public Health 64: 205-210. [crossref]
  16. Kumar S, Jain R, Saini R (2021) Confirmatory factor analysis and gender invariance of the Four Basic Dimensions of Religiousness Scale in India. Psycholog Relig Spiritual 13: 53-62.
  17. Wasdani KP, Prasad A (2020) The impossibility of social distancing among the urban poor: the case of an Indian slum in the times of COVID-19. Local Environ 25: 414-418.
  18. Mishra M, Majumdar P (2020) Social Distancing During COVID-19: Will it Change the Indian Society? J Health Manag 22: 224-235.
  19. Qazi A, Qazi J, Naseer K, Zeeshan M, Hardaker G, et al. (2022) Analyzing situational awareness through public opinion to predict adoption of social distancing amid pandemic COVID-19. J Med Virol 92: 849-855. [crossref]
  20. Lahiri A, Jha SS, Bhattacharya S, Ray S, Chakraborty A (2020) Effectiveness of preventive measures against COVID-19: A systematic review of In Silico modeling studies in indian context. Indian J Public Health 64: S156-S167. [crossref]
  21. Nihlén Fahlquist J (2021) The moral responsibility of governments and individuals in the context of the coronavirus pandemic. Scand J Public Health 49: 815-820. [crossref]
  22. Masters NB, Shih S-F, Bukoff A, Akel KB, Kobayashi LC, et al. (2020) Social distancing in response to the novel coronavirus (COVID-19) in the United States. PLoS One 15: 1-12.
  23. Fullerton MK, Rabb N, Mamidipaka S, Ungar L, Sloman SA (2021) Evidence against risk as a motivating driver of COVID-19 preventive behaviors in the United States. J Health Psychol
  24. Huynh TLD. Does culture matter social distancing under the COVID-19 pandemic? Saf Sci 2020;130:104872. [crossref]
  25. Wagner W, Hayes N (2005) Everyday Discourse and Common Sense: The Theory of Social Representations. London: Macmillan Education UK; 2005.
  26. Michie S, West R, Amlôt R, Rubin J (2020) Slowing down the covid-19 outbreak: changing behaviour by understanding it. BMJ Opin
  27. Ghader S, Zhao J, Lee M, Zhou W, Zhao G, Zhang L (2020) Observed mobility behavior data reveal social distancing inertia. PsyArXiv
  28. Simonov A, Sacher SK, Dubé J-PH, Biswas S (2020) The Persuasive Effect of Fox News: Non-Compliance with Social Distancing During the Covid-19 Pandemic.
  29. Bourassa KJ, Sbarra DA, Caspi A, Moffitt TE (2020) Social Distancing as a Health Behavior: County-Level Movement in the United States During the COVID-19 Pandemic Is Associated with Conventional Health Behaviors. Ann Behav Med 54: 548-556. [crossref]
  30. Yan Y, Malik AA, Bayham J, Fenichel EP, Couzens C, Omer SB (2021) Measuring voluntary and policy-induced social distancing behavior during the COVID-19 pandemic. Proc Natl Acad Sci USA 118: e2008814118.
  31. Beca-Martínez MT, Romay-Barja M, Falcón-Romero M, Rodríguez-Blázquez C, Benito-Llanes A, Et al. (2021) Compliance with the main preventive measures of COVID-19 in Spain: The role of knowledge, attitudes, practices, and risk perception. Transbound Emerg Dis 3: 10. [crossref]
  32. Salmon CT, Poorisat T, Kim SH (2019) Third-person effect in the context of public relations and corporate communication. Public Relat Rev 45: 101823.
  33. Briscese G, Lacetera N, Macis M, Tonin M (2020) Expectations, reference points, and compliance with COVID-19 social distancing measures.
  34. Ben-Asher S, Wolff R (2014) Privacy as a social mechanism for maintaining inconsistency between identities. Pap Soc Represent 23: 1-22.
  35. Clarke CE, Niederdeppe J, Lundell HC (2012) Narratives and images used by public communication campaigns addressing social determinants of health and health disparities. Int J Environ Res Public Health 9: 4254-4277. [crossref]
  36. Brooks SK, Webster RK, Smith LE, Woodland L, Wessely S, et al. (2020) The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet 395: 912-920. [crossref]
  37. Cattin P, Wittink DR (1982) Commercial Use of Conjoint Analysis: A Survey. J Mark 46: 44-53.
  38. Saroglou V (2011) Believing, bonding, behaving, and belonging: The Big Four religious dimensions and cultural variation. J Cross Cult Psychol 42: 1320-1340.
  39. Kirk RE. Experimental Design. In: Weiner IB, Schinka JA, Velicer WF, editors. Handbook of Psychology. Wiley; 2012 23-46.
  40. Gofman A, Moskowitz H (2010) Isomorphic Permuted Experimental Designs and Their Application in Conjoint Analysis. J Sens Stud 25: 127-145.
  41. Bellissimo N, Gabay G, Gere A, Kucab M, Moskowitz H (2020) Containing covid-19 by matching messages on social distancing to emergent mindsets—the case of North America. Int J Environ Res Public Health 17: 1-10.
  42. Provencher C (2011) Towards A Better Understanding of Cognitive Polyphasia. J Theory Soc Behav 41: 377-395.
fig 1

Effectiveness of Therapy with Hyaluronic Acid and a Mint Olfactory Substance in the Treatment of Olfactory Dysfunctions in Patients with Post-Viral Hyposmia-Anosmia

DOI: 10.31038/JCRM.2022531

Abstract

Introduction: Sense of smell represents an important system with a great impact on our life, since it allows recognizing the chemical signals from the environment and its direct involving in routine life. The loss of smell leads to a critical issue in patients’ life. The olfactory disfunction is a result set up by many etiologies; from posttraumatic to neurodegenerative disorder. Our study focused on patients afflicted by general post viral olfactory deficiency since they represent the largest number and the etiopathogenesis is related to olfactory mucosa degeneration. Idiopathic anosmia and anosmia related to rhinosinusitis were excluded given the unknown cause and the chronic phlogistic process they related to, respectively.

Objective: Human olfactory processing is determinate by the smell perception of the nasal olfactory epithelium, localized in the upper part of nasal cavities. This precious nervous structure can be damaged by multiples agents such as virus, chemical substances. During the years, olfactory training, with its daily exposures to a range of odorants, proved to be an important means to enhance the olfactory disorder. Patients with post viral olfactory disfunction can improve their impaired smell sense through olfactory training practice to restore its physiological function. The objective of our study is to evaluate the effectiveness of an olfactory training made of two substances, the Hyaluronic Acid (HA) and mint flavor in the treatment of post viral olfactory disfunction.

Methods: 150 patients with olfactory disfunction were enrolled in our study and divided in three groups of 50 each one. The patients underwent to a treatment based of hyaluronic acid, known for its reparation tissue quality, and a precise pure olfactory stimulus represented by the mint flavor to stimulate regeneration of olfactory neurons. Every group was submitted to a precise olfactory therapy (hyaluronic acid, mint flavor solo or the dual combination) for three months, twice a day.

Results: The data display the dual treatment of hyaluronic acid combined with mint improved the impaired olfactory perception by 50% of their optimal value. Hyaluronic acid associated with the pure mint olfactory essence found out to be more effective than the use of both materials alone and have a more valuable statistic data (p < 0.001).

Conclusions: Hyaluronic acid, with high molecular weight and hydrophilic nature, can form viscous water solutions and has uninflammatory properties, while mint oil is well-known to stimulate the olfactory and trigeminal nerve. Our study aimed to evaluate the effectiveness of administrating the two substances in the treatment of post viral olfactory pathologies. We concluded the two substances can be associated in the olfactory training with mostly higher results than the two used alone.

Keywords

Anosmia, Hyposmia, Olfactory training, Hyaluronic acid, Mint

Introduction

An unimpaired sense of smell allows us to perceive the chemical signs the environment is made of, by doing this, the sense contributes to determinate significantly the quality of our lives. One of its main characteristics is focus on the attention toward the hazards and positive items ordinary life is characterized. The smell is considered chemical warning sensor for safety issues, and is directly involved in the social relationships [1].

Nowadays it is well known smell disfunction is increasing with age, with a higher prevalence in male than female. The prevalence of the sense disfunction in the population has been reported between 9,5 and 15,3% [2,3].

As it regards the smell nervous processing, the whole system is based on a single cranial nerve that mediates data from the olfactory neuroepithelium to the brain. Olfactory perception starts at the level of the olfactory epithelium in the olfactory cleft, situated in the nasal cavities. The Olfactory Epithelium (OE) of vertebrates has the property to have a highly regenerative neuroepithelium which is maintained in natural conditions by a population of stem, progenitor and Globose Basal Cells (GBCs). Olfactory Receptor Neurons (ORN) are embedded within the respiratory epithelium and the axons through the cribriform plate. The key to olfactory information processing is based on the action of Olfactory Receptors (OR). All ORN converge in the same site within the bulb, called “glomerulus”. Then the fibers directly project to the pyriform and entorhinal cortices as well as to the amygdalae (“limbic system”), in memory and emotional processing [4]. Several causes, from posttraumatic injury to neurodegenerative disorders, can lead to an impaired smell function; each one with different mechanism, still not completely ruled out. Upper Respiratory Tract Infection (URTI) is one of the leading causes of post viral olfactory impairment. The precise mechanism and harm location are still unknown; nevertheless, a direct damage of the olfactory receptor cells is very likely. The affected patients usually report a spontaneous recovery which might occur within 2 years, but the improvement reported to be modest, and likely in younger patients [5]. No prognostic items predict the clinical outcome and up to now, no effective therapy exists. Despite that, a specific olfactory training, applied twice a day over a period of 3 months at least, emerged as a promising therapy in promoting the olfactory regeneration [5]. The patients with olfactory loss due to general post-infectious disease can have an increase of smell sense with olfactory training [6,7]. The pathophysiological mechanism for successful of smell training is due to involve increased regenerative capacity of neurons as a result of repeated odorant exposure and due to plasticity of the olfactory sensor. The exact mechanism is still unknown, but many studies had demonstrated the increase of the smell identification after the specific training with intense odors such as lemon, mint, and cloves. In fact, a pure olfactory stimulus is well known to increase the perception of the aromatic substance by the receptor in smell area and mint oil is renowned to stimulate the olfactory and trigeminal nerve [8]. Starting from this premises giving a pure olfactory stimulus for the smell training (mint odor) could improve olfactory functions, and its association with another regenerator tissue substance as Hyaluronic Acid (HA) could be able to speed up the recovery of the olfactory damage. The study aimed to evaluate the effectiveness of administrating a dual therapy with hyaluronic acid and a mint olfactory in the treatment of URTI post-viral olfactory disorders.

Methods

It is well known to stimulate regeneration of olfactory neurons; it is necessary to administrate a pure olfactory stimulus as a part of the olfactory training. For this reason, we decided to submit a treatment based on hyaluronic acid which is able to increase tissues reparation to a precise pure olfactory stimulus such as mint odorant. A total of 150 patients affected by post-viral hyposmia-anosmia were enrolled, and they were provided for a treatment based on a randomized in a single blind in the various defined groups. A group of 50 patients underwent a treatment with only hyaluronic acid, a group of 50 patients with hyaluronic acid plus mint and a group of 50 patients with only mint in solution. Patients were given a solution by intranasal nebulization made of ha 0.3% in association with mint 0.1% as pure olfactory essence. They were treated twice daily for a period of 3 months.

Before starting the therapy, every patient underwent an endonasal endoscopy in order to verify the absence of organic obstruction at the level of the olfactory fissures and spheno-ethmoidal recess bilaterally. All patients then underwent the Sniffin Sticks test kit from Dresden university which involves: standard identification test (the patient is exposed for a few seconds to 16 felt-tip pens with different smells and has to choose between 4 possibilities), discrimination test (the discrimination test requires to where three olfactory elements are submitted to him with eyes closed, two equal and one different, he must indicate the one different from the two, identification of the substance is not necessary) and threshold test (used to verify the minimum concentration at which the patient can perceive an olfactory substance). The sum of the scores from the three subtests resulted in the TDI-score (Threshold, Discrimination, and Identification) with a maximum of 48 points. The test was performed before the treatment and after one month of the end of the treatment. The primary end point is given by the number of patients who have recovered the olfactory function (Table 1). The secondary end point (Table 2) is given by:

1) The number of patients with the 50% improvement compared to the basal

2) The number of patients with the 25% improvement from baseline.

The statistical analysis used for the data was Fisher’s Exact Test significant for “adjusted” P-Values less than 0.05.

Our study was approved by ethical committee IARA1202015 – 1.2.2015

Table 1: Analysis of Primary Endpoint

Statistical Model Information

Statistical Test Fisher’s Exact Test
Tails for discrete tests Two-tailed
Strata weights None
P-value adjustment Permutation
Number of resamples 1000
Seed 764511

Statistical data used for analysis

Table 2: Analysis of 1st Secondary Endpoint

Statistical Model Information

Statistical Test Fisher’s Exact Test
Tails for discrete tests Two-tailed
Strata weights None
P-value adjustment Permutation
Number of resamples 1000
Seed 764511

Statistical data used for secondary endopoint analysis

Results

All groups are homogenous for gender; age and the time of begin of the pathology (Table 3). The medium age is equal in all three groups of patients. The onset of hyposmia is various from 9 to 11 months. The TDI score before the start of the treatments is from 19 to 22 score. All the patients underwent to the therapy and concluded the cycle of therapy, medical control and Sniffin Sticks test. According to the data analysis, HA in association with the pure mint olfactory essence is more effective to improve olfactory perception by 50% of their optimal value than the use of both treatments alone (Figure 1) and it demonstrated to have a more valuable statistic data (p<0.001).

Table 3: Patients data and result of sniffing stick test

Hyluronic alone

Hyluronic + mint

Mint alone

Medium age

54

56

56

m/f

25/25

27/23

24/26

TDI score before treatment

20

19

22

TDI score after treatment

22

31

23

Time iposmia begining (month)

10

11

9

P-value

P=0.2

P<0.001

P=0.198

The medium age of the three groups is uniform.

The age of the three groups is uniform.

The beginning of iposmia is similar in the three groups.

TDI: The better result is in the group of patients treated with hyaluronic acid plus mint, this is statistically significative.

fig 1

Figure 1: TDI Score.
The value of the TDI of the three groups after therapy. The better results is the group treated with hyluronic acid with mint that results statistical significative p<0.001.

Discussion

Post viral olfactory disorders following Upper Respiratory Tract Infection (URTI) are documented in many studies and typically associated with common cold or influenza. The exact pathogenesis and location of the epithelial damage caused by URTI remains still unclear, even if a damage of the olfactory receptor cells is very likely. The onset of the olfactory disease is typically sudden but many patients delay the medical consultation since they assume the smell deficit is just transient. The olfactory loss is indeed too often underestimated, both from medical and patient points of view. The smell sense is usually considered as a “forgotten sense” and its importance is realized only when it is missing. Furthermore, the diagnosis and treatment of patients come too late in order to be useful to restore proper olfaction’s functionality. For this reason, it is useful to investigate accurately the olfactory loss in every patient referring smell impairment after an URTI episode, so that the damage can be treated as soon as possible. Spontaneous recovery can occur in about one third of patients with postviral olfactory diseases and it is more frequent in younger patients than in the elderly [9]. The individual prognosis is challenging to make and no clinical factors are predictable of a good outcome. It is known the longer the disease has been lasting, the less likely is a recovery, although a timing of 2 years represents the highest chance of recovery [10]. Nowadays, no effective therapy still exists but olfactory training appears to be promising in increasing the regeneration of olfactory function [11]. The olfactory training can be helpful in the recovery of smell loss. The training consists in exposing patients with smell loss with selected odors twice a day for over a period of 12 weeks. The utility of olfactory training in a group of patients with olfactory loss due to post-infectious, posttraumatic or idiopathic etiologies was investigated by Konstantinidis et al. In this study forty of these patients underwent the olfactory training twice-daily with 4 odorants: rose, eucalyptol, lemon, and clove, and they compared the final result, tested with Sniffin Sticks test, with the patients who did not perform olfactory training [12]. They found out the training group significantly improved at 12 weeks, whereas the non-training group did not [12,13]. Even group Geißler et all. demonstrated improved psychophysical test scores following prolonged training (32 weeks) [14]. In a randomized, controlled multicenter study, Damm et al. demonstrate that olfactory training with high odor concentrations resulted in greater improvement than very low odor concentrations [15]. So far olfactory training has gained successful results and suggests it may be a helpful supplement for recovery in patients with smell loss.

As it is known, the damage of smell function is often caused by an injury of the sensory epithelium, the harm, at first, causes alterations in the mucosa and receptors, and often causes alterations of the nerve transmission along the course of the olfactory nerve. The repair of damage in the olfactory area is the first action to be encouraged, keeping in mind that the olfactory area has the intrinsic property of continuously regenerating itself over life’s course. This feature is linked to the presence of a significant amount of stem cells, which have the potential to transform themself into olfactory neurons. Hyaluronic Acid (HA) is an extracellular matrix component consisting of glycosaminoglycans with long polysaccharide chains with molecular weights from 1 kDa up to 8 MDa. HA is produced in the cytoplasmic membrane of mammalian cells by three Hyaluronic Acid Sintetasis HAS membrane enzymes. HAS-1 is responsible for the production of medium to high molecular weight HA (200-2000 kDa), HAS-2 for high molecular weight HA (2000 kDa) and HAS-3 for low molecular weight HA (< 300 kDa) [1,4,7]. HA is continuously extruded through the plasma membrane and it provides a hydrophilic viscous that facilitates cell motility, proliferation and differentiation [5,16]. Its metabolism is regulated by HAS and the plasma concentrations through hyaluronidases enzymes [3,17,18]. The hydrophobic groups and the degree of HA are important for the formation of amphipathic structures to create aggregates in water, generating physical hydrogels [19]. Hydrophobized or crosslink allow HA to have a higher resistance to biodegradation and viscous supplementation [4,20,21]. In literature, many studies had proven the effectiveness of the HA in remodeling the damage of nasal mucosa, facilitating the tissue hydration. In fact, the HA acts as a mucosal lubricant and it is able to influence the nasal bio-mechanical forces, hydric balance, cellular functions, growth factors activity and cytokines behavior. In this way the substance improves the capacity of the cell to carrier the essence to the olfactory area and keep remaining there for longer to stimulate the stem cell to be transform in olfactory receptor [22-24]. It is reported nebulized HA acts positively in determine a significant reduction in nasal exudate and inflammatory cells. It improves the microbiological status, nasal respiratory patency, mucociliary clearance and regulation of mucosal glands secretion in many ENT disorders [25]. HA shown to improve not just the sinonasal symptoms, such as nasal obstruction, but even the olfactory ability in CRSsNP patients [26]. All things considered, HA can be considered effective in modulation of the inflammatory response, being a useful tool for the improvement of reactivation of the normal tissue functions (remodeling) [22-27].

In order to obtain a more successful regeneration of the olfactory tissue, we considered necessary the association of the HA with another substance as a pure olfactory stimulus. For this reason, the dual treatment was created involving HA, capable of accelerating the damage heal at the olfactory level, in association with a precise pure olfactory odorant such as mint odorant. They were submitted to patients as nebulized nasal spray, twice a day. The proposal of our treatment was to stimulate the supposed damaged area of the smell function with an early prompt therapy. The administration of the dual substances improved the olfactory function in the patients group submitted with statistically significant results. For this reason, we can say the synergy action of both elements demonstrated to act in a more effective way than the administration of the solo treatment.

Conclusion

Our study found out the combined action of HA and mint has proven its efficiency in improving the smell functionality in patients with olfactory disfunction after viral damage. Furthermore, nowadays no specific and valid treatment still exists as an option for recovery in these kinds of patients, highlighting the importance of the dual association figured out. Nevertheless, during the years olfactory training emerged as an effective improvement modality with great results in olfactory disease. Therefore, more studies will be necessary to validate this protocol of therapy, such an association with olfactory training.

References

  1. Stevenson RJ (2010) An initial evaluation of the functions of human olfaction. Chem Senses 35: 3-20. [crossref]
  2. Murphy C, Schubert CR, Cruickshanks KJ, Klein BE, Klein R, et al. (2002) Prevalence of olfactory impairment in older adults. JAMA 288: 2307-2312. [crossref]
  3. Nordin S, Brämerson A, Bende M (2004) Prevalence of self-reported poor odor detection sensitivity: the Skövde population-based study. Acta Otolaryngol 124: 1171-1173. [crossref]
  4. Smith DV, Scott TR (2003) Gustatory neural coding. In: Doty RL, ed. Handbook of Olfaction and Gustation. New York, NY: Marcel Dekker 2003:731-758.
  5. Duncan HJ, Seiden AM (1995) Long-term follow-up of olfactory loss secondary to head trauma and upper respiratory tract infection. Arch Otolaryngol Head Neck Surg 121: 1183-1187. [crossref]
  6. Skovbjerg S, Johansen JD, Rasmussen A, Thorsen H, Elberling J (2009) General practitioners’experiences with provision of healthcare to patients with self-reported multiple chemical sensitivity. Scand J Prim Health Care 27: 148-152. [crossref]
  7. Knaapila A, Tuorila H, Kyvik KO, Wright MJ, Keskitalo K, et al. (2008) Self-ratings of olfactory function reflect odor annoyance rather than olfactory acuity. Laryngoscope 118: 2212-2217. [crossref]
  8. Moss M, Hewitt S, Moss L, Wesnes K (2008) Modulation of cognitive performance and mood by aromas of peppermint and ylang-ylang Int J Neurosci 118: 59-77. [crossref]
  9. Hummel T (2000) Perspectives in Olfactory Loss Following Viral Infections of the Upper Respiratory Tract. Arch Otolaryngol Head Neck Surg 126: 802-803. [crossref]
  10. Reden J, Mueller A, Mueller C, Konstantinidis I, Frasnelli J, Landis BN, Hummel T (2006) Recovery of olfactory function following closed head injury or infections of the upper respiratory tract. Arch Otolaryngol Head Neck Surg 132: 265-269. [crossref]
  11. Hummel T, Rissom K, Reden J, Hähner A, Weidenbecher M, et al. (2009) Effects of olfactory training in patients with olfactory loss. Laryngoscope 119: 496-499. [crossref]
  12. Konstantinidis I, et al. (2013) Use of olfactory training in post-traumatic and postinfectious olfactory dysfunction. Laringoscope 123: 2013. [crossref]
  13. Goodspeed RB, Gent JF, Catalanotto FA (1987) Chemosensory dysfunction. Clinical evaluation results from a taste and smell clinic. Postgrad Med 81: 251-257. [crossref]
  14. Geissler K, Reimann H, Gudziol H, Bitter T, Guntinas-Lichius O (2014) Olfactory training for patients with olfactory loss after upper respiratory tract infections. Eur Arch Oto- Rhino-Laryngology 271: 1557-1562. [crossref]
  15. Damm M, Temmel A, Welge-Lüssen A, Eckel H, et al. (2004) Olfactory dysfunctions. Epidemiology and therapy in Germany, Austria and Switzerland. [Article in German] HNO 52: 112-120. [crossref]
  16. Brämerson A, Johansson L, Ek L, Nordin S, Bende M (2004) Prevalence of olfactory dysfunction: the Skövde population-based study. Laryngoscope 114: 733-737. [crossref]
  17. Nordin S, Brämerson A (2008) Complaints of olfactory disorders: epidemiology, assessment and clinical implications. Curr Opin Allergy Clin Immunol 8: 10-15. [crossref]
  18. Shu CH, Hummel T, Lee PL, Chiu CH, Lin SH, et al. (2009) The proportion of self-rated olfactory dysfunction does not change across the life span. Am J Rhinol Allergy 23: 413-416. [crossref]
  19. Bremner EA, Mainland JD, Khan RM, Sobel N (2003) The prevalence of androstenone anosmia. Chem Senses 28: 423-432. [crossref]
  20. Tepper BJ (2008) Nutritional implications of genetic taste variation: the role of PROP sensitivity and other taste phenotypes. Annu Rev Nutr 28: 367-388. [crossref]
  21. Hoffman HJ, Cruickshanks KJ, Davis B (2009) Perspectives on population-based epidemiological studies of olfactory and taste impairment. Ann N Y Acad Sci 1170: 514-530. [crossref]
  22. Castelnuovo P, Tajana G, Terranova P, Digilio E, Bignami M, et al. (2016) From modeling to remodeling of upper airways: Centrality of hyaluronan (hyaluronic acid). Int J Immunopathol Pharmacol 29: 160-167. [crossref]
  23. Macchi A, Castelnuovo P, Terranova P, Digilio E (2013) Effects of sodium hyaluronate 9 mg in children with recurrent upper respiratory tract infections: Results from a randomized controlled study. International Journal of Immunology and Pharmacology 26: 127-135. [crossref]
  24. Macchi A, Gallo S, G.Montrasio, Periolo A, Simoncini D (2017) Anlysys of mucociliar clearance. A new diagnostic methods and therapeutical proposal. The Rhinologist 4: 33. [crossref]
  25. Pignataro L, Marchisio P, Ibba T, Torretta S (2018) Topically administered hyaluronic acid in the upper airway: A narrative review. Int J Immunopathol Pharmacol 32: 2058738418766739. [crossref]
  26. Savietto E, Marioni G, Maculan P, Pettorelli A, Scarpa B, et al. (2020) Effectiveness of micronized nasal irrigations with hyaluronic acid/isotonic saline solution in non-polipoid chronic rhinosinusitis: A prospective, randomized, double-blind, controlled study. Am J Otolaryngol 41: 102502. [crossref]
  27. Isnard N, Legeais JM, Renard G, Robert L (2001) Effect of hyaluronan on MMP expression and activation. Cell Biology International 25: 735-739. [crossref]

Can Active Aging Reduce the Elderly Abuse?

DOI: 10.31038/ASMHS.2022643

The Phenomenon of Aging

Life expectancy has increased with increasing quality of life and health services. The aging population has grown so rapidly that it is estimated that by 2050 years, 30% of the world’s population will be aging, and this is a serious crisis. With the increase of the elderly community in any country, there is a possibility of increasing chronic diseases such as diabetes, hypertension, Alzheimer’s, dementia, etc. And these diseases can affect a person’s health ,social status and Interaction.

Term of Active Aging?

The process of transforming opportunities into health, participation and security in the elderly in order to improve their quality of life. It seems that some elderly people with cognitive disorders, disabilities, Alzheimer’s, cannot actively participate in society and their presence in society may even pose a risk to their lives (accident, fall, theft, etc.)

From the above definitions it is understood that achieving active and healthy aging is difficult but possible. Chronic disease imposes a lot of costs on the elderly and the government. Chronic diseases in the elderly are among the main obstacles to achieving these goals [1].

Elderly Abuse?

Elderly due to physiological and anatomical changes due to increasing age, retirement and decreased social activities Death of relatives and friends, child avoidance due to marriage, work or Migration is more vulnerable and at risk. One of the risk factors for the elderly is elder abuse [2]. Elderly abuse is one of the indirect predictors of death, which is difficult to evaluate.  Elderly abuse: A general term that includes doing or not doing

Performing a single or repeated behavior that causes harassment or harm a person and acted upon by someone he or she trusts, such as family and children.

The Relationship between Elder Abuse and Active Aging

Elderly people with disabilities and chronic illnesses who need the help of others to provide care seem to be more prone to abuse. Active seniors are more self-reliant, independent in their personal affairs, and do not put pressure on family members and caregivers. The higher the degree of dependence of the elderly on the family and caregiver, the greater the risk of abuse. It seems that one of the medium-term strategies for controlling the elderly  abuse is to strengthen active aging, and we have proposed solutions. Which includes the following.

  1. Survey of knowledge, attitude and practice of the elders about aging.
  2. Survey of knowledge, attitude and practice of the elders about chronic diseases.
  3. Develop regular screening programs for the elderly to prevent chronic diseases.
  4. Identify sources of stress in the elderly as an important risk factor for many diseases.
  5. Regular evaluation of drug adherence in the elderly.
  6. Reduce medication administration if possible to prevent polypharmacy and drug side effects.
  7. Develop an appropriate diet plan according to the economic and physical condition of the elderly by health centers.
  8. Develop an appropriate exercise program with the physical ability of the elderly.
  9. Follow nursing education at home.
  10. Create elderly-friendly cities appropriate physical situation.
  11. Teaching the elderly how to properly use drugs and their side effects.
  12. Identify risk factors in the life of the elderly and reduce it.
  13. Periodic evaluation of the elderly for cognitive impairment by health centers.
  14. Training self-care ability in middle age and old age.
  15. Training of physiological and pathological processes in middle age to better prevent chronic diseases of old age.
  16. Familiarize family members with the aging process in order to better support the elderly.
  17. Creating a safe environment to prevent secondary complications of the disease (falls, sleep disorders, etc.)
  18. Familiarity of the elderly with various types of abuse.
  19. Existence of protection laws for the elderly
  20. Consider financial and social support for the elderly and caregivers.
  21. Familiarity of the elderly and families with various types of abuse.

References

  1. Mansouri F, Pourghane P, Mansour Ghanaei R (2019-2020) Investigating the factors affecting the promotion of self-concept in the elderly: A review article. Cjhaa 4: 18-27.
  2. Safarkhanlou H, Rezaei Ghahroodi Z (2017) The evolution of the elderly population in Iran and the world. Statistics Journal 5: 8-16.

Gonabad City is also to Find Its Way Out of COVID-19 Pandemic

DOI: 10.31038/PSYJ.2022434

Abstract

Introduction: Health is of the most significant affairs we are in challenge based on the crisis such as COVID-19 or any others such so. We aimed to review and follow Gonabad city activities for preventing and finding a way out of COVID-19 pandemic.

Methods: In this study, different sources of information such as the news, articles, mass media, and some people’s views were investigated regarding the subject. The local mass media were also followed to know the activities being done in the city, as well.

Results: Based on priorities and potentialities and the culture ruling the city or the country, some have relied on mass-scale testing to segregate the infected ones from the uninfected ones or have had a carefully monitored, micro-managed region-specific quarantine strategy or even adopted a strategy of a national lockdown, home lockdown and quarantine, covering mask, conducting social distancing and washing hands 20 times for 20 seconds every day. Some have referred to disinfectants, using traditional drugs and some vegetables and local grasses, however, they have not shown or it does not seem to be sure of any positive and treatment impact, but a way out of stress and fear of COVID-19 pandemic for most of them.

Conclusion: The people should be aware and try to care about it and learn the protocols and health recommendations that is advised by the men and the organizations responsible in the country as they are waiting for a safe and immune way out of it.

Keywords

COVID-19, Crisis, Immunity, Social Health, Health Protocols

In December 2019, a new coronavirus (SARS-CoV-2) emerged, sparking an epidemic of acute respiratory syndrome (COVID-19) in humans, centered in Wuhan, China. Within three months, the virus had spread to more than 118,000 cases and caused 4,291 deaths in 114 countries (Up to now, COVID-19 coronavirus pandemic Last updated: August 01, 2020, 05:53 GMT: Coronavirus Cases: 17,770,530; Deaths: 683,229 and Recovered: 11,167,447), leading the World Health Organization to declare a global pandemic. The pandemic has led to a massive global public health campaign to slow the spread of the virus by increasing hand washing, reducing face touching, wearing masks in public and physical distancing [1].

The world is in a deep crisis and a dangerous challenge with no parallels to draw experiences and lessons from. In most countries the infection curve hasn’t really flattened at present and they are faced with a big crisis and if the lockdown, that is one of the preventive ways of the pandemic, is withdrawn without any proper alternative, the world must bear a potential health crisis, in spite of the fact that its lockdown continues in its current form, so many other problems such as joblessness, economic crisis, food crisis, stress, depression, suicide, divorce increasing, local and global clashes, being tired and so many problems resulted from its continuation and prolonged economic shutdown will appear to bother the populations through the world from the poor to average and the riches. Then what’s the way out? It is a big question. How the global economy be actively running while keeping the health crisis under reasonable control? A possible way out, till the COVID-19 vaccine arrives, is providing personal protective equipment (PPE) and follow the health protocols being provided and recommended to all the workers in sectors which need to be opened up on priority. We take our city, Gonabad, as a case in point but this can be true for any economy and city. Based on priorities and potentialities and the culture ruling the city or the country, some have relied on mass-scale testing to segregate the infected ones from the uninfected ones or have had a carefully monitored, micro-managed region-specific quarantine strategy or even adopted a strategy of a national lockdown, home lockdown and quarantine, covering mask, conducting social distancing and washing hands 20 times for 20 seconds every day. Some have referred to disinfectants, using traditional drugs and some vegetables and local grasses, however, they have not shown or it does not seem to be sure of any positive and treatment impact, but a way out of stress and fear of COVID-19 pandemic for most of them.

Since Epidemiological records in China suggest that up to 85% of human-to-human transmission has occurred in family clusters and that 2055 health-care workers have become infected, with an absence of major nosocomial outbreaks and some supporting evidence that some health-care workers acquired infection in their families. These findings suggest that close and unprotected exposure is required for transmission by direct contact or by contact with fomites in the immediate environment of those with infection. Continuing reports from outside China suggest the same means of transmission to close contacts and persons who attended the same social events [2]. Then, it should be believed that following the health protocols and recommendations from Ministry of Health and Medical Education or Corona virus control center in the country must be considered as a big and important way out of the pandemic at the first.

Facing the COVID-19 pandemic, Gonabad people must take decisive action to stop the spread of the virus at least in local area. In these critical and fearful circumstances, it is essential that everyone be informed about other health risks, hazards and dangers of COVID-19 pandemic and the next problems it can leave and if they are informed and sufficient information is given and presented to have a deep impact on the population, then they can stay safe and live healthy. As one of the health workers in Allameh Bohlool hospital said the in bed patients for corona virus is subsiding in Aug month and this is for more covering mask, following social distancing, avoiding of crowd, ceremonies, traditional funerals in crowd, close contact and following other recommendations and advices, that not Iran but whole the men of responsible call out and insist in the world.

Recommendations and advice for the public during previous outbreaks due to other coronavirus (Middle-East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS), human-to-human transmission occurred through droplets, contact and fomites, suggesting that the transmission mode of the COVID-19 can be similar. The basic principles to reduce the general risk of transmission of acute respiratory infections include the following: Avoiding close contact with people suffering from acute respiratory infections, Frequent hand-washing, especially after direct contact with ill people or their environment, Avoiding unprotected contact with farm or wild animals, People with symptoms of acute respiratory infection should practice cough etiquette (maintain distance, cover coughs and sneezes with disposable tissues or clothing, and wash hands) and within healthcare facilities, enhance standard infection prevention and control practices in hospitals, especially in emergency departments. WHO does not recommend any specific health measures for travelers? In case of symptoms suggestive of respiratory illness either during or after travel, travelers are encouraged to seek medical attention and share their travel history with their health care provider [3].

COVID-19, our new and may long-time guest has brought about so many different concerns for our planet living creatures and mostly, up to now, people feared and lost hope to live safe and immune, since it is too dangerous, complicated and mysterious to be prevented, controlled or be stopped [4].

Therefore, To be safe, healthy and live in peace, the people of Gonabad and all of the cities in the world also should consider the recommendations and the said advices presented based on science and standards of WHO and Iran Ministry of Health and Medical Education or their health ministries to reach the goal and prevent to overcome COVID-19 pandemic as soon as possible with low cost and time. Through cooperation, knowledge sharing, following health standard messages advised, exhibit a novel cultural effort and have a look on health workers struggling for saving lives with no stop round the clock and considering that they are also human and may be tired and washed out one day, we can defeat corona virus and let it be such as other controlled and prevented diseases and viruses that once upon a time were ruling over the planet. Hope to be such so.

References

  1. Bavel JJV, Baicker K, Boggio PS et al. (2020) Using social and behavioral science to support COVID-19 pandemic response. Nat Hum Behav 4: 460-471.[crossref]
  2. Bedford J, Enria D, Giesecke J, Heymann DL, Ihekweazu C, et al. (2020) COVID-19: towards controlling of a pandemic. The Lancet 395: 1015-1018.[crossref]
  3. Coronavirus disease 2019 (COVID-19) Situation Report – 33. Data as reported by 10AM CET 22 February 2020.
  4. Atarodi A, Atarodi A (2020) The world concerns of covid-19 pandemic in people’s daily life. EC Psychology and Psychiatry 9:10-12.[crossref]

Effects of Cognitive and Metacognitive Strategy for Developing Reading Comprehension Capacity

DOI: 10.31038/ASMHS.2022642

Abstract

Reading comprehension ability is potency of students to comprehend meaning of written texts, text details and main ideas. Furthermore, ability of reading comprehension activated learners to communicate with writers. To understand main ideas of written texts, help learners to be aware and to get particular messages from texts. Cognitive and metacognitive knowledges help readers to analyze, to summarize, to judge, and to distinguish main idea of reading texts and also more details about writer viewpoints to predicate and decision making to monitor text contents too. Monolingual students are those groups which must be aware about impacts of metacognitive strategy upon reading development and comprehension through to prepare and emanate bio feedbacks with teachers. Hence, monolingual groups have to be taught more than bilingual ones due to their low – proficiency levels and also their weak knowledge capacities about reading development strategies. Indeed, today understanding the effective strategies which help to learn language skills for all of scholars in TESOL domains is very significant, so every teacher that is aware about efficacy of those psychological strategies like cognitive and metacognitive or both; he or she is able to teach language skills particularly reading comprehension very conveniently and more productive language learning results. Without understanding reading strategy text comprehension to learn language skills is impossible.

Keywords

Cognitive strategy, Metacognitive strategy

Introduction

Reading is a cognitive activity which is essential for adequate functioning and to gain information in today’s communities. Nowadays, to outburst of researches in SL reading have been focused on readers’ strategies. Research in second language reading suggests that learners use a variety of strategies to assist them with acquisition, storage, and retrieval of information (Rigney, 1978). Comprehension or reading tactics exhibit how readers to conceive a task, how they make sense of what they read, and what they do when they do not understand. It is most emphasized in traditional ELT courses and even today is focal center of English as a foreign language instruction in some countries (Susser & Robb, 1990). Reading skill is an instrument to facilitate communicative fluency in each of other language skills. Reiss (1983) contends that “the more our students read, the more they become familiar with figurative and imaginative dimensions and also creativeness native speakers of language.” Other researchers emphasized upon importantly about reading and addressed it separately. Rivers (1981) believes that reading is most important activity in any language learning (p. 259). According to Flavell; metacognitive involves about active monitoring and subsequent adjusting and controlling of information processing. For example, it includes these elaboration strategies such as building of connected to prior knowledges, or memory strategies such as note taking. According with Pintrich (2000) that combined function of a discrepancy from self-discipline theorists through a common framework that included following factors [1-4]:

  1. Predicting, planning and activating
  2. To monitor
  3. Controlling and self-awareness
  4. Apropos reacting and reflecting

Cognitive process is a mental procedure that includes thinking strategies to solve problems, decision making, to learn new knowledge and to understand previous experiments. English language teaching as a second or foreign language (ESL/EFL) has four basic skills: reading, listening, speaking and writing which have been identified as four policies in language learning. Reading is considered especially valuable under foreign language context because it is one main source for students to achieve language content (Ediger, 2001), therefore it is important that students become advanced in reading process. Alfassi stated that students should “understand meaning of text, critically to assess message remember content, and apply new-found knowledge flexibly [5-9].

Review of Literature

Reading Strategy

Reading strategies which are important for what indicated about the way readers manage to interact with text materials and how those strategies are related to reading comprehension developments. Researchers offer a variety of theoretical definitions of reading strategies in literature, during past decades. Duffy (1993), and Richards and Renandya (2002, p. 278) stated that reading strategies means, plans for solving problems encountered in constructing meaning. According to Brantmeier (2002) reading strategies are “the comprehension processes that readers use in order to make sense of what they read.” According with Garner; reading strategies are essentially deliberate, planned activities used by active learners, over and over to remedy apparent cognitive failure. In same way, reading strategies are defined by Afferbach, Pearson, and Paris (2008) as: deliberate, goal directed attempts to control and modify reader’s efforts to decode text, understand word, and construct meanings out of text.

Reading Comprehension

Reading comprehension is perpetual developmental strategy that is to receive and to interpret encoded information of written texts. In fact, it occurs while readers are extracting and to integrate different types of text contents and then to combine them with their prior knowledges which have been stored in their memories. It is an active and also a complex procedure in which it involves to understand reading texts and to interact with them and to interact with writer’s intensions and their purposes to write text.

Reading to Understand

Reading Understanding: According with R&D Program in Reading Comprehension (RAND Reading Study Group, 2002, p. 11), often referred to as RAND Report, defined reading comprehension as “the process of simultaneously extracting and constructing meaning through interaction and involvement with written language. It consists of three elements: reader, text and purpose of reading.”

Students’ linguistics knowledge for reading comprehension:

There are several differences which affected upon reading comprehension development between L1 and L2 readers that include; linguistic level, educational proficiencies, sociocultural and also institutional differences. There are two kinds of different characters among L1 and L2 readers:

1: linguistic differences

2: processing differences

Linguistic differences: Research results revealed that L2 readers commenced their reading processes with different linguistic knowledge resources of first language readers. Ordinary, L1 students approximately know around 5000-8000 new words and expressions orally while they have six years old and when their reading abilities are being progressed. During that age, they store more enriched knowledges of morphology and syntactic structure of language. According to Koda (2007): In contrast with L1 reading, L2 reading involves two languages. Dual language involvement implies continual interaction between two languages as well as incessant adjustments in accommodating disparate demands each language imposes for this reason, L2 reading is cross-linguistic, and thus, inherently more complex than first language reading. The false cognates or near cognates had influenced upon word cognition in reader mind. Also, linguistic differences; at discourse, syntactic or orthographic levels can mislead and misconceptions for L2 readers particularly at beginning stages of learning procedures. L2 readers due to their dominancy upon two language knowledges they have a professional level about to develop standard level of metalinguistic information which to support their reading comprehension developments.

To process differences: According to that view professionals or L2 ones have a very slowly word recognition ability and also a less accurately ranges about word processing which they leaded to slowing while they began to read. In summary, while L2 readers are limited in linguistic resources and their experiences with their native language may interfere with L2 reading processing, they enjoy advantage over L1 readers in terms of experience with their native language and the world, as most L2 readers are older in age than L1 readers. Reading researchers are therefore suggested to conduct studies examining differences and similarities between L1 and L2 reading processes which will inform classroom instructions in reading comprehension. In addition, given linguistic processing, educational, developmental, and sociocultural differences between L1 reading and L2 reading, it is recommended that findings and implications from L1 reading research be examined carefully before its application to L2 reading research and instruction.

Reading Comprehension’s Relevant Models

Models provide a description and representation about different reading theories to interpret how reading comprehension process works and to which factors it has been involved. There are two important models: information processing model and multiple component models.

Methodology

Subject

Research participants has been selected among Iranian high school students in public and private departments and institutes that their gender ratios are mostly male and at least female by which their age ranges are from 15-18 years old. Total numbers of research samples are 42 mono and bilingual English language learners. That selection is randomly drafted. According to designed and distributed questionnaires among experimental groups, all of research populations divided to two groups with attention to their linguality abilities. Monolingual groups are those language learners that just know one language (their mother languages) or in fact they are L1s but bilingual populations are those language learners that speak English language fluently and accurately beyond their vernacular or native language. Language capability phenomena in research paper are ability of experimental groups in their houses and also in outside communications speech particularly L2 or bilingually are more emphasized.

Material

To complete that research article a lot of instruments is being applied.

A: Penguin English reading test which contains of several sections: message, people, places, things, fictions and facts. During test process experimental groups answered to reading questions as fill in blank options, multiple choice items, yes/no questions and short or long answer ones also cloze texts or c-tests (total time=60 m).

B: Reading between lines test, which questions are designed as documents based or DBQs.This test is for middle or high school students to improve their reading comprehension development capacities to learn new vocabulary, learning real grammatical structure, etc. Students have to answer a question according to a particular theme or topic which had a lot of primary related source documents (total time 75 m).

C: Questionnaires predetermined and administered to assess and measurement background knowledges of experimental groups about reading comprehension development abilities regarding to metacognitive and cognitive strategies with emphasized to linguality. Article has used five- items Likert scale questionnaires by which participants must selected one option from other items for their reading comprehension strategies. Semantic differential scale which has bi-polar attitudes about reading strategies or pairs of adjectives. All of questionnaires were piloted in order to their validity and reliability to use cognitive test procedure.

Procedure

Researcher considered a group of participants to complete article, understanding effects of metacognitive and cognitive strategies with regard to learner’s linguality to achieve his intended purposes. At first researcher acted to select research participants then to prepare useful instruments to perform research processes regularly. Writing questionnaire’s topic and related contend to article subject are other job of research article investigator.

To complete that article has been took times at least a month by which included two phases:

First: Reading test was administered among high school students mono and bilingual ones, total 42 EFL learners.

Second: Questionnaires have been accomplished by participants; mono and bilingual student (Table 1).

Table 1: Reading comprehension test results

Reading strategy

No M

SD

Cognitive Strategy

42

3

1.09

MetaCognitive Strategy

42

3

1

Conclusion

Reading is mental and cognitive process which combined of two abilities: The ability to decode and for comprehension. It is a cognitive ability which helps to learn new knowledges about word meanings and structures. Meta-cognitive process helps learner to monitor, self-awareness, to analyze and to control cognitive ability during reading comprehension. According with research data analysis it indicated that linguality has a significant impact upon both groups monolingual and bilinguals, especially bilingual groups. Two groups meaningfully are very different regard to applying above strategies developing their reading comprehension.

Keywords Definition

  1. Cognitive strategy: It is strategy which helps learners to organizing and summarizing to learn very conveniently.
  2. Metacognitive strategy: It is strategy by which learner think about the skill that he or she is learning and includes: reflecting, monitoring, problem-solving and think aloud.

References

  1. Afflerbach P, Pressley M (1995) Verbal Protocols of Reading: The Nature of Constructively Responsive Reading. Hillsdale, NJ: Lawrence Erlbaum Associates Inc.
  2. Kean Mark T; Eysenks W Michael. Cognitive psychology: A student handbook; 6th.
  3. Donna-Lynn Forrest-Pressley T. Gary Waller. Cognition, Metacognition and Reading.
  4. Zhang, Limei (2018) Metacognitive and Cognitive Strategy Use in Reading Comprehension, Springer.
  5. Decker Scott L, Strait, Julia Englund, Roberts Alycia M, Wright, Emma Kate (2018) Cognitive Mediators of Reading Comprehension in Early Development; Contemporary School Psychology.
  6. Taboada Barber, Ana Bueh, Michelle M, Beck Jori S, Ramirez Erin M et al. (2018) Reading & Writing Quarterly, 2018 Literacy in Social Studies: The Influence of Cognitive and Motivational Practices on the Reading Comprehension of English Learners and Non-English Learners.
  7. Hung Cathy On-Ying, Loh, Elizabeth Ka-Yee – Educational Psychology, 2021. Examining the Contribution of Cognitive Flexibility to Metalinguistic Skills and Reading Comprehension.
  8. Duke, Nell K, Ward, Alessandra E.; Pearson, P. David – Reading Teacher, 2021. The Science of Reading Comprehension Instruction.
  9. Thomas, David (2003). Improving your memory.

Opinion; Heterologus Prime-Boost as COVID-19 Vaccine Strategies: Towards a Nationwide Implementation

DOI: 10.31038/JIPC.2022211

Abstract

The specific immune priming can be either through immunization or hyper-immunization approach. Priming of mammalian animals models initiate primary immune response events leading to effector cells formation. Boost activates immune cell to be memory immune cells that are involved in the secondary immune response events. Immunization protocols based either on prime, homologous prime-boost and/or heterologous prime-boost strategies. This theme is operable both in mammalian laboratory animals and human beings. Murine, lapin and primates immune system functions are similar but not identical to that of human beings. So far concerning vaccine development and manufacture. On transition from mammalian laboratory animal to man, there may be variations in responses and/or in vaccine adverse effects. Homologous prime-boost is being the classical and traditional strategy in the national and international vaccination schedules of vaccine preventable infectious diseases for human welfare. Heterologous prime boost strategies are being less sounded in vaccine care givers and in health professional communities. Day by day current trials all over the world were conducted to uncover the validity of use of heterologous prime-boost in mass vaccination of COVID-19. Workers reached one of three conclusions as; i) it reactivate immunogenicity, reactogenicity and/or efficacy ii-Are of comparable efficacy and iii) Preference advise to apply it for mass vaccination of COVID-19. International authority recommendation in this concern is still not in hand. Though, there were few published human volunteer trails for heterologous COVID-19 vaccine strategies.

Keywords

Animal, Boost, COVID-19, Homologous, Heterologous, Prime, Vaccine

Introduction

From the down of COVID-19 till date, the pandemic is circulating, vaccine developed and emergency licensing obtained for few vaccines and vaccine adverse effects were being currently reported in vaccine all over the world. COVID-19 pan mass vaccinations pose to a number of interesting and fascinating topics among which the theme of heterologous prime-boost validity in combating the burden of the sars-cov-2 infections especially those concerning the newly rising variants [1-3]. The objective of the present opinion was to shed a light on the current experimental Coid-19 vaccine designs and vaccine strategies for the application of heterologous prime-boost theme across the globe.

Prime-Boost Theme

In any immunization protocol or schedule, the first applied vaccine shot is known as prime shot, while the following vaccine shots term as booster or boosting shots. The time period between the prime and boost shots depends onto; nature of the vaccine, nature of the receiving immune system, vaccine dose, rout of the proper administration and cautions of the manufacturer. Booster shot induce; memory B cell, memory T cell and both of the memory cells to produce mediator as that for B the antibodies and that of T the cytokines [4,5].

Mammals and Vaccine Development

Small mammalian laboratory animals are eligible for the vaccine laboratory development phase of a newly invented or known vaccines to determine; safety, identity, immunogenicity and efficacy. Efficacy in this case measured from live vaccine challenge model through calculation of morbidity and mortality rate among vaccinated and non-vaccinated test animals. Large primate animals can serve for the preclinical development of a vaccine but mostly used for clinical development of human fetal pathogen as a doublear similar to man [6,7].

Vaccine Prime-Boost in Mammals

Vaccine prime-boost theme is operable both in mammals and man. When a boost shot is of an identical vaccine nature to the prime shot. The schedule is known as homologous prime boost. While when the boosting vaccine shot is for the same pathogen but using different vaccine design and/or different strategies the protocol is termed heterologous prime-boost [5-8].

Mammals-Human Immune Simlulatin

Mammalian immune system is rather similar but not identical to the human immune system. There were found percentages of genetic relatedness between the human genome and genomics and the genome and genomics for mice, rabbit and chimpanzee [9,10]. Rabbit and chimpanzee are genetically more related to human being than mice in the major aspects of the human immune system. Shnawa [10] report about nine immune models of the lapin immune system that simulate for the human immune system among which the vaccine development models [5,6,10]. Though, on transmission from mammalian immune system models to human immune system, there found differences in the nature of in the immune response, efficacy and in the post vaccination vaccine adverse effects. What so ever the nature of these mammalian immune system differences than that of man they stand as an eligible indispensable developmental tool for human vaccine development due to high genetic and immune simulation percentages.

Prime-Boost Theme and Human Vaccine Preventable Diseases

Almost all of the human licensed vaccination schedules in the national and international vaccine list for vaccine preventable communicable infectious disease are of homologous-prime boost type and it is common notion among vaccine care giver and health professionals. Heterologous prime-boost theme is not sounded among vaccine care givers and health professionals. On limited scale it has been tried in HIV, Deng, Ebola [and now it is being experimentally in practice for COVID-19 vaccination in more than one country all over the world (Table 1) [11-15].

Table 1: Vaccines recommended for children aged 0-6 years as homologous prime boost

Bacterial Vaccines

Viral vaccines

Diphtheria toxoid, tetanus toxoid, acellular pertussis Hepatitis A
Haemophilus influenza type b[Hib] Hepatitis B
Meningococcal Influenza
Pneumococcal Measles, Mumps, rubella, polio inactivate, Rotavirus, Varicella

Source: Adapted from [11]

Heterologous Prime-Boost Time Line

DNA prime-protein boost and/or protein boost DNA boost, vector-protein, protein-vector as well as the mRNA-vector, vector-mRNA vaccine strategies were noticed all-over the timeline of heterologous prime boost vaccine designs both in mammals [16-26] and man [27-34] as depicted in Tables 2 and 3.

Table 2: The timeline of heterologous Prime Boost in small mammals and primate

Date

Vaccine Strategy Vaccine immunity

Reference

1991 Priming with live recombinant virus, boost with subunit recombinant protein More effective than either vaccines. It is considered as key principle of heterologous prime boost 16
1991 Prime with recombinant vaccine virus boosted by multiple time with mixture of HIV protein or synthetic peptide Increase in HIV specific antibodies 17
1992 First trail for Heterologous prime boost in nonhuman primates Increase In HIV specific antibody, promising and promote HIV vaccine development 18
1999 DNA-viral vector based in nonhuman primates Good protection. Good inducer to T cell mediated immunity 19
2005-2006 DNA prime-recombinant protein boost with primary HIV Env antigen in nonhuman primates Increase in HIV specific antibodies 20,21,22
2006 DNA prime-protein boost in nonhuman primates Proved effective vaccine strategy, provide active sterilizing immune protection 23
2008

2021

DNA prime-protein boost

Heterologous prime-boost COVID-19 vaccine strategy in nonhuman primate

High frequency responders, HIV specific Antibodies, functional T cell immune responses

Increase in antibody titres

Balanced Th1/TH2 cells

More CD8+ T cells response

24-26

Table 3: The timeline of heterologous prime boost vaccination strategy in human being

Date

Vaccine strategy Vaccine immunity

References

1988 Recombinant vaccine virus HIV coding gene an boosted by recombinant envelope protein First human done by the author himself by inoculating this vaccine strategy gave reasonable individual immunity 27
2005 Vector prime-Protein boost HIV vaccine strategy Induce high antibody and high CD* T cells 28
2008 DNA prime-Protein boost HIV vaccine strategy More significant immunity 21
2016-2019 Ebola heterologous prime-boost vaccine strategy 1a,1b clinical trial in healthy human beings 29,30,31,32
2021 Astrazinicka prime-Pfizer boost COVID-19 heterologous prime boost in human volunteers Significant rise in antibody titre and T cell reactivity 33
2022 Hetero and homologous COVID-19 vaccine strategies for modrena J&J,Pfizer using 458 participant Increase of 6to 73 fold in hetero and 4 to 20 folds rise in neutralizing antibodies and durable T cell mediated immunity 34

Heterologous Prime Boost Strategies and COVID-19 Vaccination

Lessons derived from mass vaccination of COVID-19, showed that the nature of the emergency licensed vaccines and vaccine strategies are of homologous prime-boost nature. Currently, there were reports in more than area across the globe showed that they were tempting heterologous prime boost strategies at an experimental levels. They reached to one of the following conclusions; i) heterologous yield more reactogenicity, more immunogenicity and efficacy than the homologous, ii) homologous and heterologous were of comparable vaccine efficacy and iii) Cautious recommendation for mass vaccination. Strategies tempted for heterologous prime boosts were; i) starting prime boost mono-epitopic followed by multi-epitopic ii) multi-epitopic followed by mono-epitopic vaccines using variable time periods, Table 4, between the prime and the booster shots. Till date no evident international health authority recommend frankly heterologous prime-boost theme in mass vaccination of human against COVID-19 [12,13,34,35].

Table 4: Heterologous, homologous prime –boost versus single vaccine dose in human beings

Priming Nature

Vaccine design and strategy Response nature

References

Prime Astrazinicka Efficacy up to 76% in day 22 to the day 90 post to single vaccine shot 34
Homologous Prime-boost Pfizer-Pfizer, Astrazinicks-Astrazinka Appreciable neutralizing ab rising and CD8+ T cells 35
Heterologous prime-boost Mix Watch of the above makes Higher Ab titre 73 fold High CD8+ T cells 35

Immune Features of Hetrologous Prime Boost both in Mammal and Man

The immune feature of vaccinated small mammals and non-human primate [36,37] as well as that for human beings [35,38,39] are depicted in Table 5. The similarity appeared to be evident in both of the cases.

Table 5: The immune features of heterologous prime boost vaccine strategies in mammal and man

Recipient Immune System

Immune features

References

Mammals; Mice And nonhuman primates i) Make use of existing vaccine candidates

ii) Produce high long term antibody titres especially the neutralizing antibody

iii) Robust germinal center responses

iv) Long term T cell responses

Balanced TH1/TH2 responses

v) High memory CD8+ cells

vi) Immunogenic and effective

vii) Improve TH1 biased T cell responses

viii) Safe, fast and economic

36

37

Human i) Safe, effective. high systemic reactogenicity

ii) Lend profile flexibility for future vaccines

38
Human iii) Increase in the levels of neutralizing antibodies

iv) Provide better protection

v) Combine the best characteristic of each vaccine to enhance the immune system

vi) Advisable to be used in shortage, emergency, low and middle income countries

vii) Heterologous give 6-73 fold rise in neutralizing ab as compared to 4-20 folds in homologous

35,39

Conclusions

Prime and homologous prime-boost vaccine strategies were classically and traditionally known among vaccine care giver and health profession involved in the vaccine community. Heterologous prime-boost, seems to be not known among vaccine workers before 1988. From 1988 onwards to 2022 the scientific community became gradually familiar with the heterologous prime-boost both in; mammals and man. Few current phase I/II human trail using mix and match vaccine strategies for COVID-19, with cautious recommendation for use in low and middle income countries. Though till now international vaccine authority recommendation for mass vaccine implementation concerning heterologous prime boost COVID-19 vaccine strategies is not in hand. Hopes in the coming couple of months or a year, the international vaccine authority be in a position able to license any of experimental and/or the field trail proved heterologous prime boost COVID-19 vaccine strategies.

References

  1. Shnawa IMS (2020) The covid-19 vaccine race, vaccine immunity and vaccine herd immunity. Clin Med Invest 5: 1-4.
  2. Shnawa IMS (2021) Immunity to Sars-cov-2 Infections. Book Publishing International. Science Domain International. India-UK.
  3. Shnawa IMS, ALFatlawi RH, Neamah AH, Abed AS (2021) Determination role of some biomarkers tests for severe Sars-cov-2 infection. Mat. Today; Proceedings, doi.10.1076. matpr. 2021-08.223.
  4. AL-Shaery MAN, Shnawa IMS (1998) The immune-adjuvant effect of sunflower oil. Vet Med J Giza 37: 291-298.
  5. Shnawa IMS (2021) Lapin immune features of experimental Escherichia coli-Pseudomonas aeruginosa combined bacterin. J Hunan Uni Natural Science 48: 388-399.
  6. Shnawa IMS (2019) Vaccine Technology At Glance. Boffin Access UK 36-48.
  7. Shnawa IMS (2016) Vaccinology At Glance. Lap Lambert Academic Publication, Germany 11-29.
  8. Shnawa IMS (2021) Animal contributions to immunology. J Hunan Uni Nat Sci 48: 330-335.
  9. Shnawa IMS (2013) Lapin Mucosal Immunology Lap Lambert Academic Publication, Germany 5-17.
  10. Shnawa IMS (2021) Lapin-Human Immune Simulation Models. Book Publishing International. Science Domain International India-UK.29-52.
  11. Levinson W, Chin-Hong P, Joyce EA, Nussbaum J, Schwartz B (2018) Review of Medical Microbiology and Immunology15th ed, McGraw-Hill/Lange, New York 273.
  12. Lu S (2009) Heterologous Prime-Boost vasccination. Curr Opin Immunol 21: 245-251.
  13. Siddiqui A, Adnan A, Abbas M, Taseen S, Ochani S, Essar MY (2022) Revival of heterologous prime-boost :An outlook from the history of outbreaks. Hlth Sci Rep 5: 531. [crossref]
  14. George JA, Eo SK (2011) Distinct humoral and cellular induced by alternative prime boost vaccination using plasmid DNA and live viral vector vaccination expression of E protein of Denge virus type2. Immune Network 11: 268-280. [crossref]
  15. Brown SA, Surman SL, Sealy R (2010) Heterologous Prime-boost HIV vaccination regimen in pre-clinical trials. Viruses 2: 435-467. [crossref]
  16. Hu SL, Kalniecki J, Sirdhar P, Travis BM (1991) Neutralizing antibodies against HIV-1BRU and SF2 isolates generated in mice immunized with recombinant virus expressing HIV-1BRU envelope glycoproteins and boosted with homologous gp 160 AIDS Res, Hum. Reteroviruses 7: 615-620. [crossref]
  17. Girard M, Kieny MP, Barre-Sinouss F, Nara P, Kolbe H, et al. (1991) Immunization of chimpanzee confer protection against challenge with human immune deficiency virus. Proc Nat Acad Sci USA 88: 542-546. [crossref]
  18. Hu SL, Abrams K, Barber GN, Moran P, Zarling JM, et al. (1992) Protection of macaques against SIV infection by subunit vaccine of SIV envelope glycoprotein 160. Science 255: 456-459. [crossref]
  19. Hank T, Samuel RV, Blanchard TJ, Neumann VC, Allen TM, et al. (1999) Effective induction of simian immune deficiency virus specific cytotoxic T lymphocytes in macaques by using multiepitopic gene and DNA prime-modified vaccine virus Ankara boost vaccine regimen. J Virol 73: 7524-7532. [crossref]
  20. Beddows S, Schulke N, Kirschner M, Barnes K, Franti M, et al. (2005) Evaluating immunogenicity of disulfide stabilized, cleaved tri-meric form of envelope glycoprotein complex of human immunodeficiency virus 1. J virol 79: 8812-8827. [crossref]
  21. Wang S, Arthus J, Lawrence JM, Ryk DV, Innocent M, et al. (2005) Enhanced immunogenicity of gp120 protein when combined with recombinant DNA priming to generate antibodies that neutralize the JR-FL priming isolate of HIV-I. Virol 19: 7933-79337. [crossref]
  22. Wang S, Pal R, Mascola JR, Chou THW, Innocent M, et al. (2006) Polyvalent HIVI envelope vaccine formulations delivered by the DNA priming HIV-I isolate subtypes A, B, C, D & E. Virol 350: 34-47. [crossref]
  23. Pal R, Kalyanaraman VS, Nair BC, Whitney S, Keen T, et al. (2006) Immunization of rhesus macaques with polyvalent DNA prime-protein boost HIV-I vaccine elicit protective antibody response against siamian human immune deficiency virus of R5 phenotype Virology 348: 341-353. [crossref]
  24. Wang S, Kennedy JS, West K, et al. (2008) Cross-subtype antibody and cellular immune responses induced by polyvalent DNA prime-protein boost HIV-I vaccine in healthy volunteers. Vaccine 26: 1098-1110.
  25. Bansal A, Jackson B, West K, Wang S, Lu S, et al. (2008) Multi-functional T cell characteristics induced by polyvalent DNA prime-protein boost human immune deficiency virus type I vaccine regimen given to healthy adults are dependent on the rout and dose administered. Virol 82: 6458-6469. [crossref]
  26. Liu J, Xu K, Xing M, et al. (2021) Heterologous prime boost immunization with chimpanzee adenoid vector elicit potent protective immunity against sars-cov-2 infection. Cell Discovery 7: 123.
  27. Zagury D, Bernard J, Cheyneir R, Desportes I, Leonard R, et al (1988) A group specific anamestic immune reaction against HIV-I induced by a candidate vaccine against AIDS. Nature 332: 728-731. [crossref]
  28. Nitonyaphan S, Pitisuttithum P, Karmasuta C, Eamsila C, Souza MD, et al. (2004) Safety and immunogenicity of an HIV subtype B and E prime-boost combination in HIV negative Thia adults. J Infect Dis 190: 702-706. [crossref]
  29. Wang QM, Sun SH, Hu ZL, Yin M, Xiao CJ, et al. (2004) Improved immunogenicity of tuberculosis DNA vaccine by DNA priming and protein boosting. Vaccine 22: 3622-3527. [crossref]
  30. University of Oxford (2016) A phase I a clinical trial to assess the safety and immunogenicity of MVA-EBOZ alone and a heterologous prime-boost with ChAd3-EBOZ in healthy UK volunteers. Clinical trial.gov.2016.Report Number NCT0Z451891.
  31. University of Oxford (2019) A Phase I b safety and immunogenicity. Clinical trial of heterologous prime boost immunization with MBOZ an MVA-EBIZ in healthy Senegalese adults aged 18-50 years. Report NumberNCT02485912.
  32. Venkatraman N, Ndiaye BP, Bowyer G, Wade D, Sridhar S, et al. (2019) safety, and immunogenicity of a heterologous prime boost EBOLA virus vaccine regimen in healthy adults in UK and Senegal. J Infect Dis 219: 1187-1197. [crossref]
  33. Gro BR, Zanoni M, Seid IA et al. (2021) heterologous chldoxin cov-19 andBNT162bz prime boost vaccination elicit potent neutralizing antibodies and T cell reactions. mdRxiv 21257971.
  34. Voyasey M, Clemens SAC, Madhi SA, et al. (2021) Sigle dose administration and the influence of the timing of the booster dose on the immunogenicity and efficacy of Chdoxin covid19 (AZD1222) vaccine a pooled analysis. Lancet 397: 881.
  35. Atmar RL, Lyke KE, Deming ME, et al. (2022) Homologous and heterologous covid-19 booster vaccination. New Eng J Med 386: 11.
  36. Lu S, Wang S, Grimes-Serrani JM (2008) Current progress of DNA vaccine studies in human. Expert Rev Vaccine 7: 175-191. [crossref]
  37. He Q, Mao Q, An C, Zhang J, Gao F, et al. (2021) Heterologous prime boost; breaking the protective immune response bottole neck of covid-19 vaccine candidate. Emerg Microbe Infect 10: 629-637. [crossref].
  38. Sapktota B, Saud B, Shretha R, Fahad DA, Sah R, et al.(2022). Heterologous prime boost strategies covid-219 vaccine. Trav.Med [crossref]
  39. Zhang R, Liu D, Leung KY, Fan Y, Lu L, et al. (2022) Immunogenicity of a heterologous prime-boost covi-19 vaccination with mRNA and inactivated vaccines compared with homologous vaccination strategy against sars-cv-2 variants. Vaccine 10: 72. [crossref]

Dereism and Commemoration: A Conceptual Review

DOI: 10.31038/PSYJ.2022433

Abstract

From a clinical viewpoint, dereism can be an evil warning sign, which may hint at disruption of thought organization, damaged reality testing, impaired insight, compromised judgement and serious mental condition. So, in the realm of descriptive psychopathology and phenomenological diagnosis, dereistic thinking or animism, demands, first of all, exclusion of organic problems, like space occupying lesions of brain, and, then, ruling out psychosis, like schizophrenia. On the other hand, dereism can be found in neuroses or personality syndromes, a finding that may indicate its multidimensional connotation. In the present article, while dereism has been appraised from psychoanalytic and cognitive viewpoints, it has been tried to delineate some of its valuable aspects, as well, which may be ignored clinically during routine psychiatric evaluation, counseling or psychotherapeutic approaches.

Keywords

Dereism; Dereistic thinking; Autistic thinking; Magical thinking; Fantasy thinking; Animistic thinking; Animism; Animatism; Animalism; Preoperational thought; Obsessive-compulsive disorder; Obsessive-compulsive personality disorder

Introduction

The process of thinking, which cannot be separated from other mental functions, has been divided into the following three types: 1) undirected fantasy thinking = dereistic thinking = autistic thinking; 2) imaginative thinking; and 3) rational or conceptual thinking. In practice, of course, these three types of thinking are not discrete but constantly intermixed [1]. Animism is the doctrine of souls and spiritual beings. It may be said that the principle governing magic, the technique of the animistic mode of thinking, is the principle of the omnipotence of thoughts. In the course of treatment, most obsessive patients are able to tell how the deceptive appearance arose in most of these cases, and by what contrivances they themselves have helped to strengthen their own superstitious beliefs. All obsessional neurotics are superstitious in this way, usually against their better judgment, which seems to have abandoned such beliefs. Thus, the omnipotence of thoughts, the overvaluation of mental processes as compared with reality, is seen to have unrestricted play in the emotional life of neurotic patients and in everything that derives from it, which resembles the barbarians who believe they can alter the external world by mere thinking [2]. In the present article, dereism and the associated items, as important psychopathologic issues, which are many times, and in line with descriptive phenomenology, ascribed to serious psychiatric disorders, have been looked over, based on the available resources and some innovative inferences, which may indicate advantageous clinical suggestions.

Background

A) Operational Definition of Dereism and Associated Issues

Dereism is defined as a mental activity that follows a totally subjective and idiosyncratic system of logic and fails to take the facts of reality or experience into consideration. So, dereistic thinking, which is known as one of the characteristics of schizophrenia, includes mental activity not concordant with logic or experience. Similarly, autistic thinking, in which the thoughts are largely narcissistic and egocentric, with emphasis on subjectivity rather than objectivity, and without regard for reality, is used interchangeably with autism and dereism and is seen in schizophrenia and autistic disorder [3]. Likewise, magical thinking is known as a form of dereistic thought and is defined as an irrational (but not delusional) belief that certain outcomes are connected to certain thoughts, words, or actions, e.g. if I hold my nose, someone will die [4]. Moreover, it is similar to that of the preoperational phase in children, in which thoughts, words, or actions assume power (e.g., to cause or to prevent events) , and a tendency to endow physical events and objects with lifelike psychological attributes, such as feelings and intentions, which is termed animistic thinking [5].

B) Cognitive Epistemology

Epistemologically, during the stage of preoperational thought (2 to 7 years of age), thinking and reasoning are intuitive and children learn without the use of reasoning. So, events are not linked by logic. Preoperational thought is midway between socialized adult thought and the completely autistic Freudian unconscious. Children in the preoperational stage cannot deal with moral dilemmas, although they have a sense of what is good and bad, and have a sense of immanent justice, the belief that punishment for bad deeds is inevitable. Also, children in this developmental stage are egocentric: they see themselves as the center of the universe; accordingly, they are unable to modify their behavior for someone else [6]. During this stage, children also use a type of magical thinking, called phenomenalistic causality, in which events that occur together are thought to cause one another (e.g., thunder causes lightning, and bad thoughts cause accidents). In addition, children use animistic thinking, and they can use a symbol or sign to stand for something else, a process that is termed semiotic function.

C) Psychiatric and Clinical Issues

Psychiatrically, persons with Hoarding Disorder (HD), which is a syndrome in the spectrum of Obsessive-Compulsive and Related Disorders, have persistent and profound difficulty discarding or parting with their possessions. As a rule, people with the disorder acquire things of little or no value and cannot throw them away. What drives the behavior appears to be the fear of losing items that the patient believes will be needed later and a distorted belief about or an emotional attachment to possessions. Moreover, though most hoarders accumulate possessions passively rather than intentionally, they perceive their behavior to be reasonable and part of their identity. Patients with HD also overemphasize the importance of recalling information and possessions, and may believe that forgetting the information will lead to severe consequences and prefer to keep their possessions within sight so as not to forget them [7]. The same pattern is observable, as well, in some demented patients, though with less reasoning or understandable impetus in comparison with HD. On the other hand, in Obsessive-Compulsive Personality Disorder (OCPD), which is characterized by orderliness, perfectionism, and mental and interpersonal control at the expense of flexibility, openness, and efficiency, and is frequently coexist with Obsessive–Compulsive Disorder (OCD), Inability to discard worn off or worthless objects with no sentimental value is, also, observable. Sigmund Freud suggested that those with an anal character are stubborn, parsimonious, and highly conscientious because of struggles over toilet training during the anal period. In addition to acknowledged Psychodynamic Factors and secondary gains that are involved in OCD, like keeping the attention of care takers, controlling interpersonal relationships and management of environmental stressors, and recognized defense mechanisms (the unconscious mental processes that the ego uses to resolve conflicts among wish, reality, important persons, and conscience), like Isolation ( separation of an idea or memory from its attached emotion), Splitting (dividing persons toward whom the patient is ambivalent, into good and bad) and FANTASY ( seeking solace and satisfaction by creating imaginary lives), Freud formulated OCD as a regression from the oedipal phase to the anal psychosexual phase of development.

As stated by him, when patients with OCD feel threatened by anxiety about retaliation for unconscious impulses or by the loss of a significant object’s love, they retreat from the oedipal position and regress to an intensely ambivalent emotional stage associated with the anal phase (1 to 3 years of age, somewhat comparable to the stage of preoperational thought). The ambivalence is connected to the unraveling of the smooth fusion between sexual and aggressive drives characteristic of the oedipal phase. The coexistence of hatred and love towards the same person leaves patients paralyzed with doubt and indecision. Accordingly, ambivalence is an important feature of normal children during the anal-sadistic developmental phase; children feel both love and murderous hate toward the same object, sometimes simultaneously. Patients with OCD often consciously experience both love and hate towards an object. This conflict of opposing emotions is evident in a patient’s doing and undoing patterns of behavior and in paralyzing doubt in the face of choices. The above-mentioned magical thinking can be found in OCD, too. In magical thinking, regression uncovers early modes of thought rather than impulses; that is, ego functions as well as id functions are affected by regression. Since inherent in magical thinking is the omnipotence of thought, people believe that merely by thinking about an event in the external world they can cause the event to occur without intermediate physical actions. Thus, the said feeling causes them to fear having an aggressive thought [8].

D) Thinking and Psychopathological Cataloging

In fantasy thinking, as is obvious, the psyche, if deprived of any adequate object, prefers to deceive itself or invent some nonsensical object rather than give up all drive or aim. So, fantasy allows the person to escape from, or deny, reality; or alternatively, convert reality into something more tolerable and less requiring corrective action. Accordingly, shy or reserved people, without any mental ailment, may use dereistic thinking to compensate for the disappointments of life. Fantasy may develop from the stage of being deliberate and sporadic into an established mode: the person comes to believe the contents of his fantasy, which becomes subjectively real and accepted as fact. Pathological lying (pseudologia fantastica), hysterical conversion and dissociation (somatic and psychological hysterical symptoms), and the delusion-like ideas occurring in affective psychosis are among the said falsifications. Anyhow, this fantastic rearranging or transformation of reality is shown by neurotic patients habitually, and all people occasionally. In imaginative thinking, there is a joined use of fantasy and memory to generate plans for everyday life, and though it does not go beyond the rational or the possible, it is not necessarily confined to solving immediate problems. On the other hand, rational or conceptual thinking is the use of logic, without intermixing with fantasy, to solve problems [9].

E) Freud’s Annotations Re Obsessive-Compulsive Neurosis, In Brief

An important mental need in obsessive patients is the need for uncertainty in their life, or for doubt. The creation of uncertainty is one of the methods employed by neurosis for drawing the patient away from reality and isolating him from the world – which is among the objects of every psychoneurotic disorder, and so may prepare the person’s perspective for dereism. Again, it is only too obvious what efforts are made by the patients themselves in order to be able to avoid certainty and remain in doubt. The predilection felt by obsessional neurotics for uncertainty and doubt leads them to turn their thoughts by preference to those subjects upon which all mankind are uncertain and upon which our knowledge and judgments must necessarily remain open to doubt. The chief subjects of this kind are paternity, length of life, life after death, and memory – in the last of which we are all in the habit of believing, without having the slightest guarantee of its trustworthiness. On the other hand, the relationship between love and hatred is among the most frequent, the most marked, and probably, therefore, the most important characteristics of obsessional neurosis. In every neurosis we come upon the same suppressed instincts behind the symptoms. After all, hatred, kept suppressed in the unconscious by love, plays a great part in the pathogenesis of hysteria and paranoia. So, the neurotic phenomena in OCD arise, on the one hand, from conscious feelings of affection which become exaggerated as a reaction, and on the other hand, from sadism persisting in the unconscious in the form of hatred (reaction formation). If intense love is opposed by an almost equally powerful hatred, and is at the same time inseparably bound up with it, the immediate consequence is certain to be a partial paralysis of the will and an incapacity for coming to a decision upon any of those actions for which love ought to provide the motive power. Also, it is an inherent characteristic in the psychology of an obsessional neurotic to make the fullest possible use of the mechanism of displacement. So the paralysis of his powers of decision gradually extends itself over the entire field of the patient’s behavior. The doubt corresponds to the patient’s internal perception of his own indecision, which, in consequence of the inhibition of his love by his hatred, takes possession of him in the face of every intended action. The doubt is in reality a doubt of his own love, and is especially apt to become displaced on to what is most insignificant and small. Accordingly, a man who doubts his own love may, or rather must, doubt every lesser thing and may endeavor to ‘isolate’ all such protective acts from other things. The compulsion, on the other hand, is an attempt at compensation for the doubt and if the patient, by the help of displacement, succeeds at last in bringing one of his inhibited intentions to a decision, then the intention must be carried out.

Furthermore, by a sort of regression, preparatory acts become substituted for the final decision, thinking replaces acting, and, instead of the substitutive act, some thought preliminary to it asserts itself with all the force of compulsion. True obsessional acts such as these, however, are only made possible because they constitute a kind of reconciliation, in the shape of a compromise, between the two antagonistic impulses. The obsessive thought which has forced its way into consciousness with such excessive violence has next to be secured against the efforts made by conscious thought to resolve it. As we already know, this protection is afforded by the distortion which obsessive thought has undergone before becoming conscious [10].

F) Freud’s Comments Re Animism, Magic and the Omnipotence of Thoughts, In Short

The terms ‘animatism’, animalism’ and ‘manism’ denote the theory of the living character of inanimate objects. What led to the introduction of these terms was a realization of the highly remarkable view of nature and the universe adopted by the primitive races, which peopled the world with innumerable spiritual beings both munificent and malicious. As said by them, these spirits and demons were the causes of natural phenomena, and accordingly, not only animals and plants but all the inanimate objects in the world are animated by them. Similarly, they believe that human individuals are inhabited by similar spirits, and the souls, which live in human beings, can leave their residences and transfer into other human beings; so, they are the vehicle of mental activities and are to a certain extent independent of their bodies. How did primitive men arrive at the unusual dualistic views on which the animistic system is based? It is supposed that they did so by noting the phenomena of sleep (including dreams) and of death, which so much look like that, and by attempting to elucidate those phenomena which are of such close concern to everyone. The main starting-point of this hypothesizing must have been the problem of death. While what primitive man regarded as the natural thing was the indefinite prolongation of life (immortality), the idea of death was only accepted late, and with doubtfulness. So, by forming the idea of the soul and its extension to objects in the external world, he kept the earlier dogmas. As stated by Hume, there is a general inclination among mankind to imagine all creatures like themselves, and to transfer to every object those abilities with which they are intimately familiar, and of which they are very well aware. Animism is a system of thought that allows us to grasp the whole universe as a single unity from a single point of view, and myths, as well, are based on animistic premises. On the other hand, it is not to be supposed that men were motivated to create their first system of the world by pure theoretical curiosity, because the practical need for controlling their surroundings must have played its part. So, hand in hand with the animistic scheme, there came a body of guidelines for how to achieve mastery over men, monsters, animals and things – or rather, over their spirits. These instructions go by the names of ‘sorcery’ and ‘magic’ as the ‘strategy of animism’. Sorcery, the art of manipulating spirits by treating them in the same way as one would treat men in similar conditions and by the same techniques that have proved operative with living men. Magic, on the other hand, disregards spirits and has to serve different purposes – it must protect the individual from his enemies and from dangers, it must give him power to injure his enemies, and it must subject natural phenomena to the will of man, like a series of rituals for producing rain and fertility. Furthermore, in magic, the element of distance is ignored; in other words, telepathy is taken for granted. Also, there is a similarity between the act performed and the result expected (‘imitative’ or ‘homoeopathic’ magic). For example, if I wish it to rain, I only have to do something that looks like rain or is reminiscent of rain. At a later stage of civilization, instead of this rain-magic, processions will be made to a temple and prayers for rain will be addressed to the deity living in it. Also, if one knows the name of a man or of a spirit, one has obtained a certain amount of power over the owner of the name. The higher motivations for cannibalism among primitive races have a comparable basis. By incorporating parts of a person’s body through the act of eating, one at the same time gains the abilities possessed by him, which leads in certain situations to restrictions and precautions with respect to diet. While association of ideas permits misidentifying an ideal connection in place of a real one, men mistook the order of their ideas in place of the order of nature, and therefore imagined that the control which they have, or seem to have, over their thoughts, allowed them to exercise an analogous control over things. It is easy to perceive the motives which lead men to practice magic: they are human wishes, like children that, to begin with, satisfy their wishes in a hallucinatory manner by creating a satisfying situation (kids’ play). As a result, as said by Schopenhauer, the problem of death stands at the outset of every philosophy; and we have already seen that the origin of the belief in souls and in demons, which is the essence of animism, goes back to the impression which is made upon men by death. While on the animistic stage, men assign omnipotence to themselves, the scientific view of the universe no longer gives any possibility for human omnipotence; men have accepted their littleness and submitted reluctantly to death and to the other necessities of nature. None the less, some of the primitive belief in omnipotence still continues in men’s conviction in the power of the human mind, which struggles with the laws of reality.

Discussion

The primitive idea of a soul, which accepts that both persons and things are of a dual nature and that their known qualities and variations are scattered between their two component slices, is identical with the dualism that is declared by our current distinction between soul and body. There is an intellectual function in us which demands unison, linking and unambiguousness from any material, whether of perception or thought, that comes within its comprehension; and if, as a result of special conditions, it is unable to establish a true connection, it does not hesitate to fabricate a false one. Systems constructed in this way are known to us not onlyfrom dreams, but also from phobias, obsessive thinking and delusions, as well.

Magical thinking, which, according to recognized manuals, is apparently more observable in OCD and OCPD in comparison with other neuroses or characters, respectively, and, accordingly, has been pronounced in addition to other psychodynamic factors, may have some characteristics which differentiate it from an unconscious defense mechanism, an explicit delusion with manifest content, or an overvalued idea with boundless process. First of all, it may not have any latent meaning that demands intensive interpretation, because it is not an unconscious desire. In addition, it may be a symbolic idea that brings to mind a series of wishes. Thirdly, it may have a provisional quality, not an enduring feature. Last of all, there is some kind of relationship or overlapping between magical thinking and animistic thinking in the said psychiatric complications or traits, which, though has been described en masse by Freud, has not been cited clearly in most known textbooks, except for reporting animistic thinking as a characteristic feature of preoperational thinking during early and middle childhood. Anyway, while magical thinking is around power, surroundings and actions, animistic thinking is around life and existence. On the other hand, though magical thinking may derive from conscious anxiety, unconscious fear, constructive or destructive yearnings, and influential desires, animistic thinking may be driven from inner wishes, internalized objects, and personified losses. Emblematically, like phobia, which involves an exaggerated fear that is apparently regarding an obvious thing, but in reality it is regarding the harm which may result from the said item, animistic thinking, as well, is similar to a firm belief in living of a lifeless entity, while in fact it may be just some symbolic repercussions of a number of ruminations or nostalgias that are attached to some objects. So, the stuff may be assumed as overestimated objects, which are associated with some reminiscence of adored persons, important events, esteemed settings, treasured surroundings, etc. Such an implication with respect to healthy or neurotic individuals, which is in addition to the common psychodynamic, anthropological, or sociological formulations, can be correct as well with respect to psychotic patients, because dereistic thinking is not limited to any specific category of age, personality or morbidity. It is part of normal development of mentality during childhood, which may elongate limitlessly into later phases of development in the shape of trait, ethos or symptom, and can be classified, accordingly, based on the personal, social and occupational functionality of the creature. While spiritualism is basically constructed through dereism or intermixed with it, no illness is mechanically attributable to dereistic or autistic thinking. For example, it has been stated that what drives the behavior of a patient with hoarding disorder appears to be the fear of losing items that the patient believes will be needed later and a distorted belief about or an emotional attachment to possessions, or overemphasizing the importance of recalling information and possessions, and patients may believe that forgetting the information will lead to severe consequences and prefer to keep their possessions within sight so as not to forget them. But, maybe the inability of a person with Obsessive-Compulsive Personality Disorder , hoarding disorder or even some cases of Alzheimer’s disorder, who is unable to discard worn-off or worthless objects with no, apparently, sentimental value, may drive essentially from emotional reminiscences, as well, which may not express visibly due to unconscious defense mechanisms like isolation. Therefore, while many times, the resistance of an obsessive person against abandoning of antique objects, old homes, aged cars and similar vintage objects are being ascribed to vicariousness, stinginess or financial conspiracy, no unfriendly or criminal reason can be found except a number of unnoticed memories regarding absent persons, vanished happiness, or missing chances; a system of valuing that is specific to such kind of apparently emotionless persons. So, discarding such memorial stuff may act as a stressor for every individual who values his or her objects of interest mystically, not fiscally. So, it is not surprising that the end result of such a process, if it comes across with constant negligence of families, can be desperateness, vulnerability, anxiety or depression. On the other hand, while subjective characterization of objects may not be robotically equal to acceptance of living of lifeless objects, personification of stuff is not limited to children, obsessive persons, schizotypal individuals or psychotic patients. Having faith in the creation of human beings from soil and the rising from the dead on resurrection day makes magical or animistic thinking allowable for countless believers and turns it into a cultural principle. So, what obsessives or schizotypal persons display more than others or psychotics believe more absolutely is nothing more than a deeply-rooted old-fashioned idea, which, though is unscientific, has no clinical significance per se without other defined criteria for diagnosis of primary or secondary psychiatric complications. In addition to internal wishes or fears in primitive people that may have facilitated the primary creation of dereistic thinking, along with its secondary gains, psychiatric symptoms, like hallucination, pseudo-hallucination or illusion, as well, along with imagination, over-valued ideation, delusions and emotional dynamics, may have assisted elaboration of dereism through olden times. It is interesting that all the aforementioned processes are still operative. Therefore, it is the task of every psychotherapist or counselor to ask patients with apparently animistic thinking regarding the significance that they may attribute to apparently insignificant objects, if it is part of the problem, and probe the related ins and outs or associations. Hence, similar to misidentification, misinterpretation and misbehavior, which may result from internal aspirations, worries and dogmas, dereism, as well, may have discoverable and accustomed roots, whether conscious or unconscious, which demand patience and enquiry by therapists, before clinical diagnosis and psychopathological labeling. Furthermore, as is obvious, some sort of parallelism is evident between preoperational stage of cognitive progress, anal stage of psychosexual development and dereism, which is facilitated by regression in adult cases of OCD, or individuals who are characterized as OCPD. So, overrepresentation of magical or animistic thinking in the said group of patients or individuals is not an accidental finding. Therefore, at this juncture, disregard for classical psychoanalytic interpretations about unconscious motivations for resorting to dereism in neuroses like OCD, or conscious exaggeration of the importance of recalling information in HD, or semiconscious trait in OCPD, another idea has been stated, which involves a conscious motivation, namely commemorative dynamics, for animistic thinking. On the other hand, while, as said by Freud, primitive men and neurotics attach a high valuation or over-valuation to psychical acts, this attitude may probably be brought into relation with narcissism and regarded as an indispensable component of it. The psychological outcomes must be the same in both cases, whether the libidinal hyper-cathexis of thinking is an original one or has been produced by regression: intellectual narcissism and the omnipotence of thoughts. Then again, in only a single field of our civilization has the omnipotence of thoughts been reserved, and that is in the field of art. Only in art does it still come about that a man who is inspired by desires performs something like the execution of those wishes and that what he does in the play produces emotive effects – due to an arty impression – just as though it were something real. So, folks speak with justice of the ‘magic of art’ and compare artists to magicians. Consequently, although spirits and demons are only projections of men own emotional instincts, such an inclination will be intensified when projection promises to bring with it the advantage of mental relief. In addition, as said by Freud, the omnipotence of thoughts, which is ascribed by obsessives to thoughts, feelings and wishes, and has been recognized as an essential element in the mental life of primitive people, may be accounted as a frank acknowledgement of a remnant of the old megalomania of infancy.

Conclusion

Though dereism, is scientifically an archaic mode of thinking, and in psychiatry, may be accounted as an important symptom, disregard to its developmental or pathologic basis of genesis, it may harbor additional implications, which have not been outlined serviceably before, except than revealing its soothing effect re inherent subjective weaknesses and endless mental conflicts of human being by expert psychoanalysts, psychologists, mythologists and anthropologists. commemorative role of what seems to be animism, though in the presence of intact reality testing, in obsessive persons, neurotic patients or any other individual, can be considered as an advantageous implication, which demands thorough exploration of beliefs and remembrances by psychotherapist, counselor or psychiatrist, before ascribing dereism to serious mental problems, which demands aggressive interventions. It is somewhat similar to post-grief mummification of recollections of a lost darling by a surviving kin or companion, whether depressed or not, though at this juncture it may involve further subjects or moods.

References

  1. Hamilton M (1974) Fish’s Clinical Psychopathology. Yohn Wright & Sons LTD. Bristol.
  2. Freud S, Totem and Taboo, Strachey J et al.(1955) The standard edition of the complete psychological works of Sigmund Freud. London: The Hogart Press 13: 1 – 255.
  3. Boland RJ, Verduin ML, Ruiz P.Glossary of Terms Relating to Signs and Symptoms. Kaplan & Sadock’s Synopsis of Psychiatry. Lippincott Wolters Kluwer.
  4. Burton N.(2010) Psychiatry. John Wiley & Sons Ltd, West Sussex, UK.
  5. Kaplan HI, Sadock BJ, Grebb JA.(1994) Contributions of the Psychosocial Sciences to Human Behavior. Kaplan And Sadock’s Synopsis of Psychiatry. Philadelphia: Williams & Wilkins;
  6. Boland RJ, Verduin ML, Ruiz P (2022) Contributions from the Behavioral and Social Sciences. Kaplan & Sadock’s Synopsis of Psychiatry.. Philadelphia: Lippincott Wolters Kluwer.
  7. Cloninger CR, Svrakic DM (2017) Personality Disorders. In: Sadock BJ, Sadock VA, Ruiz P, eds. Kaplan & Sadock’s Comprehensive Textbook of Psychiatry. Wolters Kluwer.
  8. Sadock BJ, Sadock VA, Ruiz P. (2015) Obsessive – Compulsive and Related Disorders. Kaplan & Sadock’s Synopsis of Psychiatry. Lippincott Wolters Kluwer.420 – 421.
  9. Sims A. (1988) Symptoms in the mind: an introduction to descriptive psychopathology. Bailiere Tindall, London, 105 – 107.[crossref]
  10. Freud S, Strachey J, et al. (1909) Notes upon a case of obsessional neurosis. The standard edition of the complete psychological works of Sigmund Freud. London: The Hogart Press.153 – 318.
fig 1

Biosecurity and Cyber Security Perceived Before COVID-19

DOI: 10.31038/PSYJ.2022432

Abstract

Civilian adaptation to a security regime supposes a calculation of costs and benefits that, being associated with adaptation to the health and economic crisis, reveal a common agenda between the rulers and the ruled. The review of the adaptation to security derived from the health and economic crises is the objective of this work. A documentary, cross-sectional and exploratory study was carried out with a selection of sources indexed to international repositories, considering the publication period from 2019 to 2021, as well as the search by keywords. The axes, dimensions, trajectories and relationships between the variables that reflect and determine the phenomenon were established. In relation to the state of the art, applications to the virtual classroom are mentioned.

Keywords

Adaptation to change, Public agenda, Health crisis, Citizen security, Biosafety and cyber security perceived by COVID-19

Introduction

Until April 2021, the pandemic has killed three and a half million in the world, although such a figure is questionable if deaths from atypical pneumonia are counted, inferred from excess mortality [1]. In Mexico, there are 600 thousand recognizable or deductible cases [2]. In this scenario, the perception of security is a central issue on the citizen agenda not only because of the health crisis, but also because of the economic crisis [3].

An indicator of the importance of biosecurity and cyber security is spending on insurance (Figure 1). From the year 2000 to date, an increase is seen until 2010 when a marginal decline is seen, but the date is sustainable. Mexico is located at a threshold of minimum spending on insurance against biosecurity and cyber security risks.

fig 1

Figure 1: Insurance spending by OECD countries. Note: Prepared with data from the OECD (2021)

The United States of America is the largest insurance contractor, followed by the Japanese and the French (Figure 2). In other words, a greater propensity for risks is observed in the North American market with respect to the Asian or European one. Mexico is located in a spurious zone, very little spending on insurance relative to the OECD average.

fig 2

Figure 2: Figures in dollars for insurance

Other indicators associated with insurance show an increasing trend as the indicators are broken down (Figure 3). In other words, biosecurity and cyber security are transversal axes whose risk perception is observed in indicators that reflect them as central issues on the public agenda. Mexico is located in a deficit area of insurance spending compared to half of the countries that invest in insurance and belong to the OECD.

fig 3

Figure 3: Biosafety and cybersecurity indicators. Note: Prepared with OECD database (2021)

In this way, the escalation of violence against vulnerable groups such as children, women and the elderly has increased exponentially and adds to the risks posed by the pandemic. Derived from this situation, the perception of security emerges, develops and consolidates as a central issue on the citizen’s agenda [4]. It is a phenomenon in which potential victims see the pandemic as unpredictable in its effects, immeasurable in its consequences, and uncontrollable by the authorities.

Such phenomena, the pandemic and security, converge in violence against vulnerable groups as a result of the frustration of family heads in the face of unemployment, hunger and poor health [5]. In this way, the areas of greatest risk are the most densely populated, such as Mexico City, mainly in the Iztapalapa mayor’s office.

Precisely, the objective of this work is to review and discuss the biosecurity and cyber security perceived in the face of the pandemic, confinement and violence towards vulnerable groups such as the elderly, women and children with respect to the head of the family, civil and health authorities, exploring the perception of security by reviewing seven dimensions: territorial, national, public (government), human, public (self-protection), private and internet user.

The discussion on the relationship between the dimensions of security has been oriented from their integration as indicators of social representation [6]. It is a process in which citizens move from the objectification of kidnappings, homicides, robberies or extortions spread in the media towards their anchoring and naturalization as risk scenarios distinguishable by sectors, zones and spaces. In other words, the fragmentation of data, images or speeches in electronic networks generates levels of security that citizens perceive as far away from worrying about their situation. Or, it assumes the risks as very close to apply voting strategies of contact with people, services or activities in unsafe areas.

This social representation of security is a framework to interpret the effects of the pandemic on the personalization of security [7]. If the media broadcast institutions, hospitals, neighborhoods and sectors affected by the community transmission of the coronavirus, then the audiences will build a public agenda segmented into dimensions that reflect their fears and expectations regarding the pandemic and its collateral effects.

What are the axes, dimensions, trajectories and relationships between the variables that explain and reflect the adaptation to the SARS CoV-2 and COVID-19 pandemic?

The premise that supports this work suggests that adaptation to change and cost benefit are the axes of discussion around the SARS CoV-2 and COVID-19 pandemic [8]. This is so because a level of social despair has been reached that translates into the establishment of an agenda focused on the use of devices outside confinement as a central strategy in the face of the health crisis [9]. By virtue of the degree of overcrowding, ventilation and stay, adaptation to change acquires levels of exposure to risk and coping behaviors in the face of the situation [10]. In this sequence of costs and benefits, the perception of risk reveals a structure of decisions and actions based on the demands of the environment and the internal resources of the civil sectors.

The contributions of the study to the discipline are 1) systematic review of the state of the art, 2) systematization of findings, 3) discussion between the findings and the literature reviewed, and 4) modeling of the variables and 5) design of pedagogical sequences. Thus, in the first section, the theoretical and conceptual approaches that explain the phenomenon are reviewed. The second section presents the results of studies related to the topic. The axes, trajectories and relations between the variables are proposed. These findings are discussed to reflect on the contribution and application of the study in the classroom.

Theories of Biosecurity and Cyber Security

In this section, the theoretical and conceptual frameworks that explain the relationship between biosecurity and cyber security are reviewed, considering their representation in the governed with respect to the public administration of the matter [11]. There are at least three phases: objectification (security as a crime prevention instrument), anchoring (crime prevention as a tool of the rule of law) and naturalization (speech attributing responsibility to the government).

Based on the three phases: objectivation, anchoring and naturalization, the theory of social representations places security as an image with meaning and a precautionary sense as long as the public administration reflects a consistent policy. This is so because citizens generate a representation of their current and future authorities based on their experiences with past authorities. This is the case of elections when voters choose the outgoing public administration based on punishment.

However, the process of representing security warns of continuous and permanent learning by citizens, as well as feedback with new symbols issued in the media and electronic networks [12]. In this way, the rulers and the ruled build a public security agenda that includes permanent and ephemeral axes and topics of discussion. This relationship between the administration of past, current and future security materializes in decisive episodes for the evaluation of the authorities and crime.

Citizens build symbols that identify their government with criminality, guiding its performance as an indicator of corruption. Or, archetypes associated with civil protection, idolizing their State as omnipresent and all-powerful [13]. In this synchrony of corruption and prevention, those who make decisions on public policies contribute to the image, prestige and reputation of their institution. If these decisions obey a synchrony with the administration of justice, then an isomorphism is appreciated. It is a transfer of government values and norms towards crime prevention that citizens value as the image of their government. This is the case of the inter-institutional coupling in matters of cooperation for the extradition of cartel leaders.

However, the theory of social representation insists that the theory of governmental isomorphism is limited in that it does not consider civil participation in the incidence of the public agenda and municipal policies [14]. In turn, for the isomorphic perspective, the analysis of the administration of power is distinctive of advanced democracies with respect to transitional political systems. This distinction suggests that advanced governance, although it includes civil participation in the corporations of order, is guided by institutional mechanisms and protocols that regulate the balance of power rather than concentrating it on an individual, group or crowd.

Meanwhile, the theory of representations suggests that, in matters of security, crime prevention and rehabilitation, the State is the guarantor of said process and the citizenry should only cooperate with the election, scrutiny, questioning, debate and establishment of a public agenda.

For its part, institutional theory recognizes that the public security administration bases its operation on isomorphism or the transfer of public policy protocols to local agencies [15]. In order to be able to guarantee the continuity of the programs, regardless of the government’s ideology, both representational and institutional approaches suggest that the crime prevention strategy be carried out. Both perspectives assume that the differences between the rulers and the ruled dissolve in the face of an insecurity problem, but they forget that the asymmetries between political and social actors intensify with the increase in homicides, robberies, kidnappings or extortion.

Both the institutional and representational views believe that the State should be the guiding axis of security, but they avoid the conflict between the governors and the governed when executing the protocols for preventing and combating crime [16]. Although an authority that is distinguished by its attention to complaints, capture of delinquents or rehabilitation of criminals generates a favorable image, it is also true that the multiplication of criminal groups is concomitant with the deprivation of liberty of their leaders.

Such issues are raised by both institutional and representational perspectives, suggesting the dissection of security by dimensions that allow anticipating risk scenarios and collaboration between the parties involved. This security governance system supposes the emergence of biosecurity and cyber security as guiding axes of the agenda, discussion, agreements and co-responsibility between public and private sectors. The way in which the relationship between the categories has been addressed is through models.

Biosecurity and Cyber Security Models

Security has been of concern to the authorities and civil society in recent years. The substrata of different societies have different perceptions about security. This, in several countries, has suffered from a lack or absence, particularly when it comes to government participation. Public security can be understood as the work of the State to protect and safeguard its population from internal dangers or threats. In Latin American countries, public custody is perceived as absent, due to the large amount of press coverage that exposes the aforementioned lack [17].

In the case of Mexico, day after day a greater amount of red news coverage appears in the news, which shows a violent face of the country. It deals with the structure of the perception of security in: Territorial security; National security; Public Safety (State as Attorney General); human security; Public security (self-protection); Private security; and, internet user perception of security, scope [18].

The literature distinguishes each of the dimensions based on observing differences between groups and people with respect to events, areas, systems or risk scenarios [19]. The common denominator lies in the calculation that individuals make regarding costs and benefits around the risks, as well as the attribution of responsibility to their rulers. In the case of the pandemic, its effects are asymmetric between those who assume that the State must manage mitigation and those who assume co-responsibility between citizens and authorities.

Public safety events like pandemics occur all over the world, posing a threat to personal safety, property, and national defense. Mexico’s security problems are similar to the general context in Latin America in many ways. However, Mexico is influenced by organized crime due to the levels of consumption of illegal products in the US market [20]. The North American drug trade, when associated with the confinement of families, fosters an environment of health risks [21].

It is stated that the perception of our reality is subjective, just as our world depends on our living conditions, operating from a higher order, a mesosystem that would include both, and in which each one appears as elements and not as closed and closed units. independent [22]. The notion that what we see might not be what is really there has preoccupied and tormented the entire population in every sector, class or role of our society. A different sector of the population would have a different expectation of security.

The administration of public security is the implementation of public policies that justify the orientation of the State in the prevention of crime and the administration of justice, but only the distrust of citizens towards the action of the government is evidenced in a growing perception of insecurity reported in literature, in seven dimensions: territorial, national, public (government), human, public (self-protection), private and Internet user [23].

Mexico can be seen from various fields such as economic, historical or social. In this sense, there are other sub-scopes ( sub-scales in the social sphere) such as health, public safety, education, environmental awareness, among others. As mentioned above, different sectors of the population have a different perception of the social sub-scopes (or subscales) [24].

From the theoretical, conceptual and empirical review, the relationships between the variables were modeled. In this way, territorial and national security are concomitant given their level of generality in the protection of the country, as well as the multilateralism involved in international or regional pacification measures. In the cases of public and citizen security, both share the imperative of safeguarding common goods that, although public, can be established as socially and environmentally available for future generations. In this sense, private and digital security are also similar in terms of preventing crimes that threaten the dignity and integrity of the individual and not of society.

The relationships between security perceptions are consistent with the observed data. This is so because the measurement of the seven security dimensions is presumed, as well as their consistency when applied to other scenarios and samples [25]. In addition, security as a multidimensional phenomenon suggests levels of measurement that are concomitant with each other, reflexive and with errors attributed to the variance of the responses.

Concomitant hypotheses refer to the covariances between the dimensions of the phenomenon, as well as to the explanation of its trajectory structure if a new specification or model were to arise when testing the null hypothesis. The reflective hypotheses allude to the relationships between the factors with respect to the indicators, suggesting the structuring of the phenomenon, as well as the convergence of the responses to the reagents that measure each feature of the dimensions [26]. Measurement error hypotheses refer to unexplained variations in the estimation of the structure of concomitant and reflexive relationships. In addition, it suggests the probable incidence of other factors and indicators not included in the model.

The theory of the perception of security alludes to converging dimensions with respect to trust between the rulers and the ruled. In this way, the central premise of the theory is that citizens have unfavorable or positive expectations of their authorities in charge of law enforcement and crime prevention, as well as social rehabilitation [27]. In this sense, security is a sociopolitical phenomenon, but reduced to media expectations of government action, as well as mistrust or empathy for its strategies, programs or policies in terms of safeguarding the integrity and dignity of its governed, as well as private property and public interests.

The dimensions of this perception of security have been structured in socio-spatial terms such as the territory or in social issues such as the nation, but with emphasis on the situation of sectors, strata or groups such as the so-called citizens and citizen security, as well as particular interests such as private and Internet security [28]. In the case of cyber security, the discussion lies in the protection and safeguarding of identity and personal data.

However, the dimensions of security converge in cyber security. The unconfirmed information disseminated on electronic networks about the risk events associated with climate change and the pandemic have generated an area of study concerning the infodemic [29]. In this way, territorial and national security have traditionally been the perspectives most approached from the sociology of risk to account for the impact of climate change on sea level and coasts, as well as risk events derived from droughts, frosts, fires, floods or earthquakes in vulnerable areas, human trafficking , species or the appearance of epidemics due to the invasion of animal territories. The dissemination of the media on these problems, associated with the confinement of people, has generated an oversupply of content, resulting in two logics: Verisimilitude and verifiability.

In the first case, alluding to credibility, the impact of the media and networks on their audiences and users supposes the influence of their content based on the demonstration of risks through images. Consequently, responsibility is attributed to the State to the extent that public administrations with similar risk events are compared. Such a process has been exacerbated during the pandemic with the intensive dissemination of unconfirmed notes.

Precisely, the second case regarding the verifiability of the information supposes an expectation based on the demonstration of data, but limited to the description of risk scenarios and probabilities of affectation. This is the coverage of risk events from comparatives of public policies, although reduced to trends of expert opinions.

Within the framework of plausibility and verifiability, the so-called biosafety focuses on food as the main indicator of the level of health in the face of a health or environmental crisis [30]. In this sense, territorial or national security should have specialized in public matters because each sector or social stratum demanded different needs according to contingent situations. Citizen security gave way to the individualization of expectations and resources, giving rise to both personal and virtual self-protection, with the emergence of cyber security.

There are more differences between biosecurity and cyber security, but both are essential for the rule of law, the administration of justice, the prosecution of crime, social rehabilitation and collective pacification. From a traditional perspective, both dimensions are observable as complementary, but from a progressive approach they are assumed to be concomitant.

In other words, the effects of climate change are increasingly linked to identity theft, extortion or co-optation, since computer crimes originate from the niches of environmental and social deterioration. Cyber security observes in real time the data of robberies, kidnappings or homicides in situations of natural disaster or health contingencies.

Studies of Biosecurity and Cyber Security

Studies of adaptation to change have focused on the validity of the instruments by estimating their internal consistency with alpha and omega parameters, as well as the adequacy and sphericity for factor analysis and structure adjustment.

Seven investigations stand out on adaptation to change in scenarios of violence and insecurity derived from geopolitical conflicts or racial cleansing, as well as immigration and human trafficking:

Mendoza et al. [31] propose the perception of territorial security as the expectations about the governing State of public peace. The variable refers to the territory protected by the State in a context where invasions extended or disappeared empires. Adaptation to change was rooted in the preservation of the territory rather than in the preservation of lineage or the prevalence of race, uses and customs, all of which were mixed with the invading culture. Only in the case of Greece, which, when invaded by Rome, not only preserved its mythology but was also plagiarized by the medieval empire.

García et al. [32] raise the perception of national security as the expectations about the State as the attorney for crimes against democracy, national identity or the interests of the population. It is a scenario of adaptation of the modern state to industrial revolutions. The identity of the State as the repository of power was in crisis and the rulers allocated their resources to the propaganda of a national identity and union in the face of invading forces. The preservation of the territory was no longer enough, but the construction of a common good that will differentiate one culture from another.

Quintero et al. [33] conceptualize the perception of human security as expectations generated before crime prevention policies, the administration of justice and the promotion of social peace. It is a conglomerate of humanist approaches from which the center of the universe is no longer the nation state but rather the individual with values and idiosyncrasies that little by little will generate sufficient intellectual capital as a weapon for the accumulation of state power and resources.

Carreón et al. [34] suggest that the perception of public security refers to the expectations that citizens generate from distrust of the State and alienation with its security institutions, while interest is focuses on civil self-protection resources. The advent of civil rights and with it the new relationship between State and society directed the concern to an internal issue. The internal affairs of the nation state were now on a public agenda after the expression of sectors and no longer in the wishes of the ruler.

Mejía et al. [35] point out that the internal perception of security refers to the expectations that Internet users consider generated from the spy State and their search for information, selection of content and dissemination of topics. It is an agenda specialized in propaganda, anti-propaganda and against propaganda. Political and social actors debate around the surrounding information on government performance and electoral preferences. The impact of security policies on voters generates a media agenda and promotion of the party in power or the opposition.

Juárez et al., (2017, p. 23) define the perception of citizen security as the expectations regarding the State as attorney general. It is a conglomeration of social demands that the government in turn raises as central axes of its agenda, but based on the expectations of voters or the proximity of the elections. Unlike internal security, where the main thing is to obtain votes, propaganda aimed at civil security emphasizes national identity in the face of crime.

García et al. [36] warn that the perception of private security refers to the expectations of civil society generated from the State as incapable of preventing crime and fighting corruption. Even organized civil sectors state that the problem lies in the State as the rector of security, since it is pragmatically related to the citizenry based on the propaganda of fear of crime.

The studies confirm the factorial structure of the perception of safety, although the research design limits the findings to the research sample, suggesting the extension of the work towards the expansion of the factors. The adjustment values and residual parameters used led them not to reject the null hypothesis regarding the significant differences between the theoretical relationships established in the literature with respect to the empirical relationships found in the study.

Method

A documentary, exploratory and cross-sectional study was carried out with a selection of 100 references alluding to biosecurity and cyber security during the period of the pandemic from November 2019 to May 2021, considering the search by keywords in the Google repository (Table 1).

Table 1: Descriptives of the sample

Abstract

Repository Author   Shows Instrument Trajectory
e1 Academy Mueller 2021 71 references Biosecurity and cybersecurity inventory

Cyber biosecurity ← biosecurity

e2

Copernicus Pieralisi et al., 2021 20 references Biosafety Inventory Biosafety ← cyber security
e3 Dialnet Elgabry 2020 6 references Biocrime Inventory

Biocrime ← Biosafety

e4

Ebsco Salem & Jagadeesan 2020 13 references Biosafety Inventory Biosafety ← Institutional coordination
e5 Latindex Gomez et al., 2020 15 references biosecurity inventory

Biosafety ← Standards

Note: Prepared with study data

The Systematic Review Inventory was used, considering five extractions of findings qualified by expert judges in the axes, themes and discussion categories in three rounds. The first phase related to the qualification of the contents (1 for dominant biosecurity, 2 for hegemonic cyber security and 3 for prevailing cyber biosecurity). The second round refers to the feedback between the judges, after a comparison report of averages with their scores from the first round. The third instance related to the reconsideration based on the comparative data of the second phase.

The data was processed in the statistical analysis package for social sciences (SPSS version 20), considering the parameters of normal distribution, contingency and probability proportions in order to achieve a model of structural equations to observe their axes, trajectories and relationships in around biosecurity and cyber security with respect to the five selected extracts.

Results

The values of the parameters of normal distribution, contingency and probability ratio suggest that relationships prevail between the categories of biosecurity, cyber security and cyber biosecurity with respect to the reviewed findings. The three categories prevail as axes and are related to each other with respect to a threshold of permissible risk. In other words, the findings reflect the random effects of COVID-19 in an ordinal way as it spreads from biosecurity to cyber biosecurity (Table 2).

Table 2: Instrument Descriptives

table 2

Note: Prepared with study data: E: Extract; e1: Mueller (2021), Pieralisi et al., (2021), e3: Elgabry (2020), e4: Salem & Jagadeesan (2020), e5: Gomez et al., (2020), R: Ronda, R1: Qualifying, R2: Feedback, R3: Reconsideration, C: Category, C1: Biosecurity, C2: Cybersecurity, C3: Cybersecurity, M: Mean, SD: Standard Deviation

Once the relationships between the categories and extracts were established, the structural equation model was estimated, considering the pairing between the variables (Figure 4).

fig 4

Figure 4: Structural equation model. Note: Prepared with study data: E = Extract; e1 = Mueller (2021), Pieralisi et al., (2021), e3 = Elgabry (2020), e4 = Salem & Jagadeesan (2020), e5 = Gomez et al., (2020), R = Ronda, R1 = Qualifying, R2 = Feedback, R3 = Reconsideration, C = Category, C1 = Biosecurity, C2 = Cybersecurity, C3 = Cybersecurity

The fit and residual parameters ⌠ 𝜒2 = 13.24 (14 df ) p > .05; GFI = .990; IFC, 997; RMSEA = .008 ⌡suggest the non-rejection of the hypothesis regarding the differences between the revised structure and the model established in this study. It then means that the categories and extracts configure a structure that can be established with more extracts as long as they allude to the relationship between biosecurity and cyber security.

Discussion

The contribution of the present work was to establish the modeling of biosecurity and cyber security, considering a review of the literature, as well as a selection of five findings that were associated with the categories, being observable a structure where these five extracts are related to the prevailing categories. . In relation to three meta -analyses of the categories in the COVID-19 era where they recognize a scarcity of studies and risks of bias in the samples , the present work has observed a subtracted structure from the qualification of expert judges in the matter.

Tarakji et al. [37] conclude that studies on the effects of COVID-19 are neither specific nor conclusive. In the present work, it has been shown that biosecurity and cyber security have been merged into cyber biosecurity as an indicator of the impact of COVID-19. Such a process can be seen in the insurance expenditure of OECD countries, as well as in the qualification that judges make of the studies related to the association between the categories.

Yu & Chang [38] showed that the literature consulted revolves around industrial biosecurity together with the use of cyber security technology. In the present work it has been established that cyber security is linked to biosecurity and even generates a new order called cyber biosecurity to explain the impact of the pandemic on information systems and public health.

Bastos et al., [39] showed that the COVID-19 serological studies reviewed have a high risk of bias. In the present work, the risk of bias is tolerable, suggesting the extension of the study to other repositories and categories of analysis. Lines concerning the reduction of the risk of bias will make it possible to notice the relationship between biosecurity and cyber security once the pandemic is over.

Lines of research related to the effects of COVID-19 on biosecurity and cyber security will allow warning of bias risk scenarios in the literature published since 2019. Such a question will allow anticipating strategies based on permissible risk thresholds when making decisions by consulting the literature. specialized in cyber biosecurity.

Conclusion

In relation to the theory of the perception of security, which proposes nine dimensions related to territory, nation, citizenship, public, private, human and internet, this work found that human security is the factor that reflects the structure of perceptual security. The lines of study referring to the dimensions of human security will allow us to notice scenarios of conflict between the rulers and the ruled, as well as the emergence of citizen and private security.

Regarding security studies where a continuous coercive and persuasive State stands out in its relationship with citizens, this work has discussed human security as a dimension that explains the differences and similarities between the rulers and the ruled. The development of this dimension will allow us to notice the transition from a coercive system to a persuasive one. That is to say, the security attributed to the legitimate violence of a democratic government will be observed up to the security that demarcates the regime from all responsibility and burdens the citizen with the attribution of prevention by confining their expression and their property.

Regarding the seven dimensions of the perception of security, the present study has proposed that these explain the variance and warn of the appearance of a common factor that the literature identifies as second order. The lines of research on the emergence of this common factor will allow evaluating, accrediting and certifying the relations between rulers and rulers in matters of multidimensional security.

Perceived security is a multidimensional psychological phenomenon since it derives from the relationships between authorities and citizens with respect to crime prevention, the administration of justice and social rehabilitation, although other dimensions such as sectoral or media security to explain the impact of policies, strategies and programs on civil decisions and actions.

In Mexico, a common interpretation or idea of which country lacks security prevails. The absence of custody is influenced by the presence of organized crime, the illegal sale of drugs and weapons, and the corruption available in each branch of government, among the main aspects.

The correlations of reliability and validity when the unit shows so far that there are other dimensions linked to the construct. In this sense, the inclusion of self-control explains the effects of state propaganda in crime prevention, law enforcement, and peace education on the lifestyles of civilian sectors [40-45].

Studies on citizen security identify government expectations as the predominant factor that explains the phenomenon as an efficient, effective and effective institution, but in this paper the emergence of this phenomenon has been demonstrated from a structure of perceptions around the personal, citizen, public, human, national and territorial agenda.

References

  1. World Health Organization (2021). SARS CoV-2 and Covid-19 coronavirus statistics. Geneva: WHO
  2. Pan American Health Organization (2021). SARS CoV-2 and Covid19 coronavirus statistics. New York: PAHO
  3. Aguilar JA (2021) Social work towards a network of violence. Research Advances.10: 1-5
  4. Molina MR (2021) Compare a model of security perception in the Covid-19 era. Journal of Community Medicine and Public Health. 8: 1-6
  5. Carreón J, García C, Blanes AV (2018b) Networks of violence around the governance of public security. Social Sciences. 4 : 60-65
  6. Hernandez J (2020b) Specification of a model of sexual violence. british journal of Medical and Health Science. 2:1-4
  7. Sandoval FJ (2020) Labor expectations in the face of risk events and collateral social effects. International Journal of Humanities, Social Sciences and Education. 7:1-7
  8. Garcia C (2021) Perception of security in the face of the pandemic caused by the SARS CoV-2 coronavirus and the Covid-19 disease. Epidemiology International Journal. 5:1-8
  9. Hernandez J (2020a) Specification of a social intervention model against Covid-19. Biomedical Journal of Scientific and Technical Research. 26: 62-65
  10. Garcia C (2020a) Specification of a model to study risk perception. Reget. 24: 1-8
  11. Garza JA, Hernandez J, Carreon J, Espinoza F & Garcia C (2021) Contrast of a model of the determinants of tourist stay in the Covid-19 era: Implications for biosafety. Tourism and Heritage. 16 : 1-13.
  12. Carreón J, Bustos JM,Bermúdez G, Espinoza F & García C (2020) Attitudes towards the pandemic caused by the SARS CoV-2 coronavirus and the Covid-19 disease. Invurnus. 15: 12-16.
  13. Nájera M, Bustos JM, Carreón J & García C (2020) The perception of risk in university students in the face of the spread of the SARS CoV-2 coronavirus and the Covid-19 disease. Psychology. 8: 94-107.
  14. Bustos JM, Garcia C & Juarez M (2020) Perception of security against Covid-19. Academic Research Without Borders. 13: 1-26.
  15. Molina HD, Garcia ML, Garcia ME, Carreon J & Garcia C (2020) A statistical approach to the behavior of the Coovid-19 outbreak in mainland China. Tepexi. 7: 6-16.
  16. Molina MR, Coronado O, Garcia C & Quiroz CY (2021) Contrast a model security perception in the Covid-19 era. Journal of Community Medicine and Public Health Care. 8: 77-83.
  17. Rincon RM, Juarez M & Garcia C (2018) Interpretation of speeches around the mobility habitus to reveal the meaning of public transport. Margin. 90 : 1-13.
  18. Bustos JM,Ganga FA, Llamas B and Juárez M (2018) Contrast of a prospective decision model and implications for a university governance of sustainability. Margin. 89: 1-16.
  19. Garcia C (2020b) Specification of a model for the study of insecurity systems. Global Journal of Management & Business Research. 20 :7-10.
  20. Carreón J, Blanes AV and García C (2018a) Reliability and validity of a model of perceived governance of insecurity. Without Border. 11: 1-53.
  21. Aldana WI, Rosas FJ & Garcia C (2018) Specification of a model for the study of the public security agenda. Atlanteans. 9: 1-20.
  22. Juárez M, Carreón J, Quintero ML, Espinoza F, Bustos JM & García C (2017) Reliability and validity of an instrument that measures the dimension of the perception of safety and risk in students of a public university. International Journal of Advances in Social Sciences and Humanities. 11: 23-13.
  23. Martinez E, Anguiano F and Garcia C (2018) Governance of social works towards a network of violence. Science Learning Educational Journal. 6:1-3.
  24. García C, Carreón J and Hernández J (2017a) Governance of public safety. Literature review for a discussion of the state of knowledge of criminal sociopolitical identity. Margin. 84: 1-17.
  25. Amemiya M (2020) Retrospective meta -analysis of the random and homogeneous effect of the validity of the risk perception scale. American Journal of Applied Scientific Research. 10: 25-35.
  26. Rivera BL (2020) Exploratory structural algorithm of the perceived risk factor International Journal of Invention in the Humanities and Social Sciences. 10:26-30.
  27. Carreon J (2020) Neural networks of scenarios, phases and discourses of Internet violence. Journal of Neurology and Neuro Toxicology, 4:1-9.
  28. Garcia C (2019) Exploratory factorial structure of the security public. Journal of International System. 23:82-86.
  29. Quiroz CY (2019) Meta- analytic retrospective of transportation risk management policies in Mexico City. NetJournal of Social Science. 7: 92-100.
  30. Hernandez J (2019) Harassment on the Internet in the documentary and expert agenda. Asian Journal of Science and Technology. 10:1-3.
  31. Mendoza D, Carre ón J, Mejía S and García C (2017) Specification of a model of propaganda representations in older adults in the face of public safety. Tlatemoani . 25:21-31.
  32. Garcia C, Carreon J & Hernandez J (2017b) Co-management as a security device for local sustainable development. Eureka, 14:268-289.
  33. Quintero ML, Hernandez J, Sanchez A, Molina HD, Garcia C (2017) Model of expectations regarding public safety in microentrepreneurs in central Mexico. Borderless. 10 : 1-20.
  34. Carre ón J, Hernandez J, Garcia C (2017) A theoretical review for the study of the governance of public safety. Epsys , 4: 1-15.
  35. Mejía S, Carreón J, García C (2016) Psychological effects of violence and insecurity in older adults. Eureka. 13 : 39-55.
  36. Garcia C, Carreon J & Hernandez J (2016) Governance of terror to crime. Eureka. 13:168
  37. Tarakji B, Alali FM, Alenzi A, Nassani MZ (2020) Systematic review with no meta- analysis of coronavirus Covid-19. Macedonian Journal of Medical Science. 30 :108-111.
  38. Yu H & Chang H (2020) A meta-analysis of industrial security research for sustainable organizational growth. Sustainability. 12 : 9526-9546.[crossref]
  39. Bastos ML, Tavaziva G, Abidi SK, Campbell JR, Haraoui LP, etal (2020) Diagnostic accuracy serological test for Covid-19 systematic review and metaanalysis. BMJ.
  40. Elgabry M (2020) Biocrime and Covid-19. Security and Crime Science. 19 : 1-2.[crossref]
  41. Gómez M, Isaza MP, Ibañez C (2020) Let’s guarantee the quality of respiratory samples to diagnose Covid-19. Nova. 18 : 93-98.
  42. Mueller S (2021) Facing the 2020 pandemic: What does cyberbiosecurity want us to know to safeguard the future? Biosecurity & Health, 3 : 11-21.[crossref]
  43. Organization for Economic Cooperation and Development (2021). Statistics insurance . Giinevra : OECD
  44. Pieralisi N, Souza GN, Iwaki VLC, Chicarelli M, Tolentino SE (2021) Biosecurity perspectives in oral and maxillofacial radiology in time in coronavirus disease (Covid-19) a literature review. International Journal of Odontosomatic , 15 : 77-81.[crossref]
  45. Salem SB & Jagadeesan P (2020) Covid-19 from food safety and biosecurity perspective. Open Food Science Journal, 12: 1-12.[crossref]

The Cultural Psychology of Religion and Political Ideals: Political Liberalism as a Protoevangelium?

DOI: 10.31038/PSYJ.2022431

 

In his first letter to the church in Corinth, Paul remarks memorably that perception of divine truth is comparable to seeing “as through a glass darkly” (1 Corinthians 13:12 New International Version). For a number of contemporary Christians, the glass through which humans might perceive dimly the truths of the Christian faith is thought to have grown darker over the past two centuries due, in part, to the manner in which the culture of advanced political democracy has undermined revealed religion—has rendered more opaque the light of Christian faith. One villain in this view is the environment of meaning supported by political liberalism, an ecology formed by widely disseminated decrees of courts and legislative bodies as well as by a set of cultural expectations concerning the scope of justice realizable through state power, an expectation growing from, and reinforced by, the juridical and legislative pronouncements of the liberal state itself. Such an ecology of meaning is held by some Christians to have created an environment in which traditional Christian faith is perceived as marginal, or, worse, as harmful [1]. Hence, it is claimed that humanity’s capacity to know God, if only imperfectly, is made even more difficult by the rise of political liberalism and the symbolic universe it delimits: a world of governments always unmoored to churches or other religious institutions, a world, as a result, where the decisions of states can defensibly and intelligibly be grounded not on revelation but only on natural science, and where, partly in consequence of the state’s firm pursuit of justice, the morally serious pursue not transcendence, but the rectification of injustice in this life, unconcerned with a justice beyond the here and now—the justice dispensed to an immortal soul. These features of the culture of contemporary liberalism—separation of church and state and the resultant elevation of science as the basis of state decision making, and the overarching concern with overturning on earth injustice and the associated loss of the persuasive appeal of divine justice in a future life—have made much darker the knowledge of God’s truth, creating, it is claimed, a “culture of disbelief” [2].

In this work I develop, on the contrary, the hypothesis that the ideas created through the mediation of liberal courts and legislatures, and the cultural expectations that ensue, have forged a set of meanings that, although they may well have some of the consequences certain Christians decry, also, if seen in a proper light, have the power to incline the mind to conceive as plausible basic propositions of the Christian faith. Specifically, I hypothesize that the world in which church and state are separated and science brought to the forefront of culture, and the world in which the men and women whom all can agree to call heroes are those who seek to press as far as possible the redress of injustices in this life—in other words, the world of contemporary political liberalism—is an environment that might incline the mind to think in terms that are deeply consistent with, and thus open to, traditional Christian claims. The world of liberalism communicated through the instrumentalities of the state and through political culture, when viewed in a particular light, can help to prepare the mind for the acceptance of Christian faith: as a result of the cultural environment it creates, political liberalism can represent a kind of proto-evangelium, or presaging of the Christian message. The purpose of this work is not apologetic, however, but psychological: it is to deploy the insights of the cultural psychology of religion to suggest the internal complexity of the universe of meaning associated with liberalism and its potential to push thinking in directions not previously appreciated.

In the first section, I outline recent work in the cultural psychology of religion that demonstrates cogently the importance of this area of psychological research. Second, I provide an outline of basic tenets of traditional Christian thought and the cultural fora through which these understandings emerged. Third, I describe two concepts central to contemporary liberal political thought and the communicative technologies and cultural media that have facilitated their development. Fourth, I review briefly the claim made by certain Christians that political liberalism creates a system of reference and cultural ideals that militates against Christian truth-claims. In section five, I argue that the two principles of liberalism on which I focus can be hypothesized to support a system of cultural signs that point toward the plausibility of traditional Christian claims. In the sixth and final section, I lay forth a research agenda of qualitative inquiry designed to test the hypothesis that political liberalism can bear a fruitful connection to traditional Christian belief.

i) The Cultural Psychology of Religion

The cultural psychology of religion is a subfield in psychological research that, as J.H. Pak [3] notes, “focuses on understanding human behavior in the social context by taking into account environment, history and culture.” Using these insights, it studies the “generation of categories for understanding” the world individuals’ find themselves in, and their religious responses to it (p. 171). Cultural psychology is especially useful as one tool in the psychological study of religion since, as J.A. Belzen recounts [4], religiosity “is a culturally constituted phenomenon in which psychic life expresses itself.” (p. 25). Concretely, Pak, echoing D. Polkinghorne’s famous inventory of psychological research methodologies [5], notes that the cultural psychology of religion is an approach based on qualitative inquiry guided by a well-defined and plausibly-grounded hypothesis (Pak, p. 171). It is thus unmoored to large quantitative data collection research. However, it is not meant to replace quantitative analysis; it is meant, rather, as one tool to augment the study of the psychology of religion with theories derived from assessments of cultural-ecological effects on religious belief and practice. Lastly, the cultural psychology of religion is especially receptive to interdisciplinary analysis (Pak, 180), a point that will become important in the development in our last section of a future interdisciplinary research agenda.

ii) An Outline of Orthodoxy Christianity

Traditional, or orthodox, Christianity is certainly not univocal, but, for present purposes, it can be defined as a set of propositions and ideals derived from oral church tradition and ritual practice, scripture, and conciliar pronouncements, most centrally the creedal declarations of the Nicean and Constantinopolitan church councils. What many today call orthodox Christian thought, therefore, emerged through the communicative technologies of orality, collective practice, written exposition, and collaborative debate in the form of ecumenical councils comprised of leading church officials. These technologies forged the environment in which men and women came to define themselves as orthodox. Orthodoxy can thus be studied as the product of specific communicative strategies: the collection of oral tradition and ritual observances, the writing down and continual passage over time in written form of these traditions, and the collective debate and discussion of the true meaning of the claims found in oral and written material.

One abbreviated outline of the substance of orthodox thought can be adumbrated in the following way. All that exists in any space or any time is the result of an act of a creator god. This being created first a time and a place somehow anterior to the time and space we experience in our ordinary lives. In this place the creator made humanity from the substance of the earth. Here, the humans the creator made lived in harmony with their maker, the entire created world was peacefully and harmoniously directed toward god, and humans were, within their own psychological makeup deeply at peace. However, through a transgression by the first humans, the initial condition was radically altered. By force of this transgression, divine punishment came to be executed. The souls of the first humans became disordered and their orientation was turned away from their god. And the natural world itself also was wounded. Since the initial transgression and the resulting punishment, instead of being harmoniously directed toward god, the natural world became a captive of decay, etched with suffering, locked in ruthless competition, and travailed in pain—groaning for its ultimate redemption (Romans 8: 21-23). As the Book of Isaiah recounts: “the earth languishes…for a curse is on the earth” (Isaiah 24: 4-6). Indeed, “cursed is the ground because of you [Adam and Eve]” (Genesis 3:17). This altered state was a punishment visited not only on the perpetrators themselves but on all the humans who followed the initial pair. The creator gave to the later generations a punishment—a disordered soul, an orientation away from god, a natural world marked by decay, enmity and discord—for a transgression that they themselves did not commit, a penalty that makes it hard, or perhaps even impossible, for any human on his or her own to secure god’s favor. Through the redemptive act of Jesus Christ, however, atonement for the transgression is given. Humans who are in some way followers of the redeemer will then be resurrected in a new heaven and a new earth, in which there will be the restoration of internal balance for individuals; the reorientation of humankind to god; and the healing of the violence that marks the natural world, for, in that new place, “the wolf shall dwell with the lamb, and the leopard shall lie down with the kid; and the calf and the young lion” will live in harmony, with “the wolf and the lamb feeding together.” Indeed, “they shall not hurt nor destroy” in the abode of the new creation (Isaiah 11:6; 65:25).

iii) Contemporary Liberalism: Two Central Concepts

Contemporary liberalism is a complex and often amorphous set of ideas and aspirations. It has been shaped in the crucible of a distinctive set of institutions: standing courts issuing written decrees accessible through print media, and representative bodies assembled to address matters of public concern, informed in their deliberations frequently by the technology of representative polling, and issuing written laws accessible to the mass of society. The emergence and continued maintenance of liberalism depends on these (or very similar) institutional structures and communicative technologies. At least several constellations of ideas are central to the culture created by political liberalism. First, as Robert Audi and others have maintained, the concept of the separation of church and state is indispensable to contemporary liberal political thought [6]. Moreover, this separation is often viewed as deep and wide. The proper functions of the state should not include any meaningful promotion of religion at all.

Related to this strict separationist viewpoint is the idea of science as the privileged, even exclusive, means of state decision making. Since the state should not promote religion, policy making must not be based on claims derivable from scripture unless they can independently be verified by a non-religious source, most frequently the natural or social sciences (Audi, 2000). Science is privileged because its claims are held to be reproducible in empirical experiments, and are held to be subject to continual revision and testing through on-going debate and discussion in the forum of scientific conferences and publications.

With a strict separation of church and state has come the political and cultural elevation of science. As Oxford theologian Roger Trigg has argued, science has assumed the status of an alternative system of truth that takes the place of religion in the decision processes of government (2007, p.198). An example of this development can be seen in recent debates surrounding public school curricula. In the celebrated case of Kitzmiller v. Dover Area School [7], the United States District Court held that the decision as to which textbooks to assign in a public school had to be made in a way that was untinctured by the influence of any concepts even remotely religious; the decision as to which textbooks for a public school district to accept is a governmental decision that has to be made solely on that basis deemed the most purely scientific, a basis allowing no influence, however indirect, for religious concepts or ideas.

Another idea integral to contemporary liberalism is at least the aspiration that humans will treat injustice as a summum malum to be combated tirelessly as a highest duty. Liberalism has developed through the instruments of government power, specifically court rulings, legislative enactments, and executive orders. A central preoccupation of the liberal state has been to advance the cause of justice for individual citizens seen as free and equal members of the political community. Courts have perhaps most visibly advanced the cause of ensuring justice, understood as the fair and equal treatment of all citizens. Indeed, as Thomas Woods, Kevin Gutzman, and Thomas Sowell have argued, through the mediation of the court system and its printed decrees accessible to all in society, liberalism has grown into a set of cultural norms defined by an expansive and deeply ambitious claim that men must strive to rectify all human injustice [8,9]. From this overarching concern to redress injustice in this life has emerged dilated concepts of restorative justice. Several of such very ambitious attempts to right human wrongs can be found in the policy of affirmative action, in school desegregation, and calls for reparations for African slavery.

Affirmative action programs are born of a high idealism, the desire to take charge and make right past injustices. Injustice is so vilified, and the call to rectify wrongs in this life, without relying on divine justice in an afterlife, so powerful that affirmative action has emerged as a policy demanded by the political liberalism’s understanding of justice. Due to past wrongs, and the lingering consequences presently of the past injustices, all traces of the initial wrong must in this world be extirpated. To do so, all individuals now should not be treated strictly or fully equally, but rather, some advantage should be given today to the members of the class historically treated unfairly, even if this means that a member of a non-protected class unrelated in any direct way to the perpetration of the initial injustice is denied a strict conception of equal treatment. Perhaps the clearest articulation of this understanding of racial justice was expressed by Supreme Court Justice Harry Blackmun in the important affirmative action case of Regents of the University of California v. Bakke [10] when he notes that “in order to get beyond racism, we must first take account of race.” True justice, Blackman argues, demands that past injustices to African Americans be rectified to the point of treating whites who had no role in the imposition of earlier injustices in a way that can in effect prove to make their admission to college harder.

In respect to primary and secondary school desegregation, in Swann v. Mecklenberg Board of Education [11] the Supreme Court authorized the busing of white students to schools with a large percentage of African American students to remedy past state-sponsored school segregation on the basis of race. As a result of this ruling—one born of a deep desire that justice be done on earth—“among the losers,” Woods and Gutzman note, “were nonblack students bused to underperforming schools, even though none of the affected children was a wrongdoer,” i.e. the children had no role in the earlier state-sponsored acts of racial discrimination (2008, p. 58). Hence, the courts enshrined a conception of justice based on collective responsibility and accountability: it rejected, Woods and Gutzman remark, an “older idea of justice” which holds that only present malefactors are to be held responsible for criminal or immoral acts and that the state should only “target the guilty party and not inflict their punishments on a broad class of individuals” not themselves responsible for previous injustice (p. 61). Indeed, when justice is pursued with such passion as evidenced by many of the rulings of the United States Supreme Court—rulings that are core features of contemporary political liberalism–it often leads to an expansive definition of justice that includes and even necessitates collective responsibility.

Moreover, in regard to the question of material reparations for African slavery the same logic often holds. Calls by international legal bodies for reparations for slavery follow the logic of expanding justice to the point of implementing liabilities based on a de-personalized and collective sense of responsibility for previous egregious offences. The Legal Committee of the Organization of African Unity, for example, has called for monetary reparations for the past injustice of African slavery, a call echoed by legal scholars such as Mari Matsuda [12,13], who all call for the legal and political systems of the western world to make material amends for the past injustice of transcontinental African slavery. Against arguments that the injustice of past slavery is no longer justiciable since (presumably) no Western individual or state today is directly responsible for any current act of transcontinental African enslavement, these legal scholars and corporate bodies argue that the injustice of African slavery was so monstrously egregious—such an affront to justice itself—that any lingering aspect of the previous injustice, say, in the form of material advantages that the Western world may still enjoy as a result of its previous acts of unjust enrichment through slavery, must be extirpated: justice demands that collective responsibility for past wrongs be born by individuals and states not themselves responsible for the earlier injustice [14]. Through calls widely disseminated in print and electronic media, the demand for reparations for African slavery has begun to have a powerful influence in Western culture. As the noted scholar of global restorative justice Richard Falk argues, the decisions of the African Union and the writings in their defense by Western legal scholars have allowed the demands for reparations to assume a good deal of the same cultural force held by legal holdings of the United States Supreme Court (2008).

iv) The Claims that Political Liberalism Undermines Christian Faith

These influential ideas—the separation of church and state and the resulting political potency of natural science, and the rise of expansive claims on behalf of justice—are thought by some conservative Christians to have undermined the Christian faith. Separation of church and state is thought by such scholars as Roger Trigg (2007) and Stephen Carter (1994) to be religiously corrosive, in part due to the representational power of the state. That is, a functioning state is an entity that will always elicit awe. The technologies of state power will always be, to some degree, awesome: even the most constitutionally restrained government will have the reserve power to field an army and to send its young people to die in combat to defend the state; and even the most minimal state intent on survival will retain the reserve power to shape in some manner the upbringing of youth, through some control over schooling to ensure a minimum of social cohesiveness; and even the most minimal state will also have the power to take away the life of egregious wrongdoers, if not literally through the instrumentalities of the death penalty, then at least in the sense of taking away one’s life as a free person through the technology of perpetual imprisonment. A functioning state of any political stripe will, therefore, always be viewed with awe, having as it does power over life, youth, and death. Since the state concerns itself with these fundamentally important things and so is always to some extent awe-inspiring, for it not to be involved at all in religion is for religion to risk being seen as not awe-inspiring, as not fundamentally important: for if religion were, how could such an awesome force as government ever be indifferent to it? (Trigg, 2007, p. 128).

By this logic, when the state bases its activities on science (and not religion), science takes on the representational gravity of the state. Science, then, tends to become fundamentally important in the mind of the people. Moreover, many Christians have come to see science as increasingly and belligerently opposed to Christian faith. The burgeoning industry of natural scientists authoring god-rejecting books [15] has not assuaged this concern. For these reasons, some Christians see the culture of political liberalism as denigrating the faith, and even as setting up a parallel pseudo-religion using the same rhetorical technologies of the earlier religion: we see sacred books disseminated by writers claiming to have firsthand knowledge of the truth, but now not in the form of Christian oral tradition derived for eye witnesses to Christ but of empirical revelations of scientists in laboratories; ecumenical councils of learned experts convene to define creedal statements, but now not as a Christian creed but as a kind of scientific conciliarism to construe the precise meaning and formulations of disbelief; and the majesty of the state becomes moored to claims of ultimate reality, but now not through a union of church and state but through an establishment of science as the state’s official confession.

Additionally, the expansive concern for justice has also been viewed by some Christians as establishing ideals that erode orthodox faith. Combating injustice is of course not seen by any Christians as wrong. What is questioned is the commitment to a bold idea to make the world fully morally clean by human law and government. The proponents of reparations for slavery, for example, seek to purge the world of lingering vestiges of injustice, a desire they pursue with such passion that they see as fair the imposition of tariffs and impediments on individuals in no way directly implicated in the sin of human bondage. Here Christian thinkers often point to Eric Voegelin as having detected a dangerous siren song. Such a project communicates the idea that the mind must be focused on straightening the crooked timber of injustice on earth, remaking by human will the whole of social relations. Voegelin refers to this kind of a mission as the call to immimentize the eschaton, a call of a secularized heart for a world redeemed by human effort (1987).

v) Liberalism as a Cultural-Psychological Proto-Evangelium? A Hypothesis.

Such Christian thinkers, however, overlook a very real sense in which the culture of political liberalism might serve to underscore the viability of central Christian claims. The culture shaped by political liberalism can be hypothesized as forging a worldview that makes more accessible key Christian concepts—however mysterious these may be in a complete sense. The conjunction of the emergence of strict separation of church and state, and the resulting elevation of the power of science, and the rise of expansive claims on behalf of restorative justice can together create an ecology of meaning that can make plausible orthodox Christian views.

Separation as we have seen leads to the high cultural valuation of science. One of the central concepts of modern science is evolutionary biology. In fact, the Dover school case mentioned above was itself about evolutionary biology. Affirming evolutionary biology as the account of the origins on this earth of life and humanity is to affirm as true an account of the world in which the natural order itself is replete with suffering. As the poet Alfred Lord Tennyson wrote, in Darwin’s world nature is “Red in tooth and claw” (1850). Darwin’s natural world is marked by severe competition and frequent genetic mistakes that result in their animal bearers being butchered on, in paraphrase of Hegel’s famous words, natural history’s “blood-soaked slaughter-bench” [16,17]. Random mutations coupled with selection through ruthless competition are the engines of development on earth.

As this evolutionary account takes a greater cultural hold, it becomes natural to look for ways that the universe itself could be seen as the result of evolution. The drive is set in place to think about worlds before the big bang, which would allow our current universe to somehow be itself a product of a larger scheme of cosmic evolution. Indeed, a large number of scientists now speak frequently of evolution being applied to the universe as a whole. Many now speak of some earlier universe; and as a part of an evolutionary mindset—which sees incredible change over time in the natural order–an earlier universe is often seen as quite likely being radically different from our current universe, there being, as evolution demands, radical change over time. Hence, a number of physicists speak now of an earlier universe with entirely different physical laws, different “domain functions.” Scientists such as Lee Smolin in his work Life of the Cosmos have popularized this idea [18]. And major scientific conferences and publications have also widely disseminated this understanding. Indeed, as astrophysicist Bernard Carr argues, due to the rise of the “multi-verse” view of the cosmos, “although conservative cosmologists might prefer to maintain the [one universe model]…history is against them” [19,20]. Or as the noted physicist and author of the popular work The First Three Minutes, Stephen Weinberg argues, the many universe model is compelling and represents “a major shift in our understanding of the universe” (2007, p. 17), a view supported by such other luminaries of natural science, and promoters of science in popular culture, as Richard Dawkins, Daniel Dennett, [21,22]. As Dinesh D’Souza points out, these ideas are now widely disseminated and well known in the broader culture (2007, pp. 133-137; Trigg, 2007, p. 192). Given the cultural importance of science in a liberal political regime, which we have explored, the multiverse idea can indeed take a powerful hold.

So the culture of liberalism bends in the direction of seeing our world as one in which, hardwired in the natural world, is violence and discord, but at the same time as a world we can increasingly suppose was preceded by an earlier world with different physical laws—laws that might perhaps be other than the savage ones of mutation, competition, and selection repeated over immense periods of time which has fashioned in this universe the beings we are today. Moreover, by the logic of cosmic evolution–that is, of an evolutionary process at work in the cosmos in its broadest sense–it is increasingly plausible to assert that there will exist in the future a world after this, also possibly with entirely different natural laws.

Importantly, we must add to this concept of cosmic multiverses the cogency of claims of collective responsibility, such as inheres in the policies of affirmative action, school busing, and slavery reparations. Liberal political culture, by supporting policies that in effect punish some people today in order to rectify injustices perpetrated by earlier generations, makes increasingly plausible the idea that the savage laws of mutation and selection could actually be visited on this world due to some action in a previous one: that this world is a world suffering its own collective punishment.

From these ideas emerge a viewpoint consistent with orthodox Christianity, a kind of presaging of the Christian drama supplied by modern scientific and political liberal presuppositions. Humans are born into a natural order that is itself deeply disordered due to the operation of savage laws of competition, mutation, selection, and slaughter—the world of Charles Darwin. As beings made of the very stuff of nature, man is therefore also born disordered. Yet an earlier world existed in which different laws controlled, and the created being or beings in that world were not subject to Darwinian laws of mutation and selection. This current world with its Darwinian laws—laws the Christian writer Henry Morris [23] describes as “monstrous, inefficient, and cruel”—could be a punishment visited collectively on later humans for the transgressions of the beings in the earlier universe. Evolutionary biology could merely depict the physiology of the Pauline letters: man’s constitution in this world is inherently marked by inner turmoil, nature is scarred by incessant competition, the natural order is “red in tooth and claw”—and thus is in need of God’s deliverance—all because of an earlier offense. Such would, moreover, be no scandal to liberal justice, since the liberal language of justice inclines the mind to accept the validity of unearned punishment, of individuals—for the sake of justice—being punished for acts they themselves did not commit. The language of liberalism affirms in effect the right to punish sons for the sins of their fathers. For despite perhaps some superficial protests to the contrary, collective punishment is indeed an inexorable consequence of the policies of an expansive understanding of justice which has come to typify political liberalism. The liberal language of justice in the context of an evolutionary worldview, therefore, creates a system of cultural signposts pointing toward the Christian message of the fall. Yet the evolutionary framework points also to the possibility of a yet other world, with different physical laws, laws that could be free from the rule of mutation, selection, competition, and death: a new heaven and a new earth.

Of course, it can be argued that both policies like reparations and the Christian concept of the fall are unjust simpliciter. But this is not the logic of either position. Liberal political thought sees its policies as representing a deeper, fuller sense of justice; and Christianity holds that the fall does not impugn God’s justice, for “the judgments given by the LORD are trustworthy and absolutely just.” (Psalm 19:9 New English Translation).

Moreover, nothing I have sketched about evolutionary science and collective responsibility speaks clearly about the Christian drama of sin and salvation; yet the reference to one who would “crush” the head of the serpent (Genesis 3:15 Berean Study Bible)—what is called by Christians the proto-evangelium, or the pre-figurement of the Christian redeemer—is itself only suggestive of things to come; it only points in a particular direction. In the same way, might we be able to call political liberalism its own form of proto-evangelium?

My argument is not one of apologetics, it is one concerning the ecology of cultural meaning as an exercise in the cultural psychology of religion—a determination of how cultural symbols are available in the context of contemporary political liberalism that can point thought in a particular direction by broadening the imagination to think in terms consistent with fundamental Christian claims. It is about how forms of thought can be made viable by their presentation and elaboration in the culture of a particular time; it is about, in all, how liberalism might cast on what Paul calls the dark mirror a shimmer of new light.

vi) An Agenda for Future Research

Interdisciplinary work among political scientists deeply conversant in liberal political ideology and the leading figures in the liberal political movement, joined by religious studies scholars deeply conversant in Christian theology, and also qualitatively-focused psychologists of religion, can test this hypothesis in the following way. In line with suggestions developed by Pak [24,25], one especially fruitful method in the cultural psychology of religion to do this would be through in-depth examination of autobiographical narratives of leading liberal activists. As Pak argues, autobiographical narratives serve to create a sense of psychological “consistency and coherence across time” (p. 180; Belzen, 2008); and they do so, McAdams notes, by how “they serve to define self, define relationships with others, and regulate emotional experiences through drawing moral and life lessons” (Pak, p. 180; McAdams, 2001). These features of narrative writings, Pak maintains, are precisely the tools that should be seized on in the cultural psychology of religion (2017, pp. 180-82). In-depth analysis by an interdisciplinary team, therefore, should review the autobiographical accounts of leaders in movements that embody political liberal ideals to assay if self-descriptions are discoverable that fit the hypothesis developed above. A study of this nature would provide important advances in the cultural psychology of religion [26,27].

References

  1. Trigg R (2007) Religion in public life: Must religion be privatized? Oxford. Oxford University Press.
  2. Carter S (1994) The culture of disbelief: How American law and politics trivialize religious devotion. Anchor
  3. Pak JH (2017) Cultural psychology of religion and qualitative research. Research in the Social Scientific Study of Religion. 28: 163-187.
  4. Belzen JA (2010) Towards cultural psychology of religion: Principles, approaches, applications. Springer.
  5. Polkinghorne D (1983) Methodology for the human sciences: Systems of inquiry Albany. State University of New York Press.
  6. Audi R (2000) Religious commitments and secular reason. Cambridge University Press.[crossref]
  7. Kitzmiller v. Dover Area School District (2005).
  8. Woods TE, Gutzman KRC (2008) Who killed the Constitution? New York: Random
  9. Sowell T (2002) The quest for cosmic justice. New York: Free Press
  10. Regents of the University of California v. Bakke, 438 U.S. 265 (1978).
  11. Swann v Mecklenberg Board of Education (1971)
  12. Matsuda M (1987) Looking to the bottom: Critical legal studies and reparations. Harvard Civil Rights and Civil Review. 22: 340-376.
  13. Thompson J (2018) Should current generations make reparations for slavery? Cambridge: Polity Press
  14. Du Plessis M (2003) Historical injustice and international law: An exploratory discussion of reparation for Human Rights Quarterly. 624-659 [crossref]
  15. Dawkins R (2008) The god delusion. New York: Mariner Books.
  16. Tennyson AL (1850). In memoriam A.H.H. London: Edward Moxon
  17. Hegel G WF (1988) The philosophy of history. Indianapolis: Hackett
  18. Smolin L (1997) Life of the cosmos. New York: Oxford University Press.
  19. Carr B (2007) Universe or multiverse? Cambridge University Press. [crossref]
  20. Weinberg S (2007) Living in the multiverse. In B. Carr (Ed.), Universe or multiverse? Cambridge University Press. [crossref]
  21. D’Souza D (2007) What’s so great about Christianity. Washington, D.C.: Regnery Publishing.
  22. Hawkings S. Multiverses. (2008). In B. Carr (Ed.), Universe or multiverse? (pp. 57-75). Cambridge University Press
  23. Morris H (1973) The Day-age theory. In K.L. Segraves (ed.), And God created. San Diego .Creation Science Research Center
  24. Belzen JA (2008) Autobiography and the psychological study of religious lives . Brill Academic Publishers.
  25. McAdams DP (2001) The psychology of life stories. Review of General Psychology. 5 :100-122.
  26. Falk R (2008) Reparations, international law, and global justice. Handbook of reparations .Oxford University Press.
  27. Voegelin E (1987) The new science of politics. Chicago: University of Chicago Press.

Significance of Immunostimulants in Aquaculture

DOI: 10.31038/AFS.2022435

Abstract

The use of immunostimulants to enhance activities in the immune system has been given considerable attention in aquaculture in order to increase disease resistance in farmed fish. Use of Immunostimulants in aquaculture is gaining importance as the other therapeutic measures like antibiotics; vaccines and chemotherapy have their own limitations. This review stated the importance of immunostimulants, its application, objectives, types, advantages and disadvantages in aquaculture. Therefore, immunostimulants were found to be most promising for used in aquaculture to control diseases.

Keywords

Immunostimulants, Aquaculture, Fish, Significance

Introduction

Immunostimulant is a natural occurring compound that modulates the immune system by increasing the host’s resistance against diseases [1-7]. Immunostimulant comprise a group of biological and synthetic compounds that enhance the nonspecific cellular and humoral defense mechanism [4]. It may be chemical, drug or naturally occurring compound that elevates the nonspecific defense mechanisms or the specific immune response of the host and may be given alone to activate non-specific defense mechanisms as well as heightening a specific immune response.

An immunostimulant is a biological or synthetic compound administered either orally or through body fluids into the body of the fish or shrimp for enhancing the immune status of the host to overcome the adverse environmental conditions, stress, pathogens and opportunistic microbes. An immunostimulant, used in vaccines to amplify the specific immune response or administered as feed additives to modulate non-specific immunity, have been demonstrated to play a role in protection against diseases in fish [3]. Phagocytic cells play an important role in the defense mechanisms of the host by adhering to and engulfing the invading particles. Such cells include tissue macrophages, circulatory monocytes, and neutrophils. There are numerous reports of microbial products having immunostimulatory qualities that enhance phagocytic activity. Such immunostimulants include bacilli Calmette-Guérin and Corynebacterium parvum [4].

Various strategies are adopted for the management of fish health. Therapeutic approaches are amongst the most direct ones, while the more efficient and aquaculture- compatible and environmentally sound means of health management involve the use of immunostimulants to enhance the general well-being and health of fish. Immunostimulants and non-specific immune enhancers mostly in the form of natural products stimulate the immune system, reduce susceptibility to diseases and protect fish from stress and diseases in aquaculture. This reduces the dependence on chemicals or drugs and minimizes the negative environmental impact. It can also render aquaculture products more acceptable to consumers. Emerging trends show that eco-friendly approaches through the use of probiotics and immunostimulants can contribute significantly to health management in fish farming [5]. Aquaculture is likely to adopt the increased use of immunostimulants as feed additives since it can improve the efficiency of the system, enhance production, reduce the use of chemicals and render aquaculture products more acceptable and safe. There is a considerable emphasis on health management in aquaculture based on prevention rather than treatment [6]. Recently a number of studies have supported the rationale in incorporating the use of immunostimulants into the overall health management plan [7]. A more efficient and health management could lead to reduced cost and stability in the production system and improve the economics of aquaculture operations. Therefore, this review is of the significance of immunostimulant in aquaculture.

Application of Immunostimulants

  • [5] conducted an extensive review on the use of immunostimulants in aquaculture. Immunostimulants can increase resistance of fish to environmental stress and are therefore suitable for use in aquaculture. They can be used in complementing the activity of vaccines. However, overdosing can lead to immunosuppression [5].
  • Immunostimulants enhance disease resistance by improving non-specific defense mechanisms. Their use, in addition to other agents and vaccines is acceptable to farmers. There seems to be a wider efficacy and greater safety with immunostimulants in comparison to chemotherapeutics and vaccines. Immunostimulants have been used as feed additives for many years in aquaculture, and yeast β-glucan may be the one with the longest track record. In nature, β-glucans are widespread and have been characterized in microorganisms, algae, fungi and plants [8]. Boosting Fish Immune System: The immune system of fish has witnessed a surge in interest over the past two decades, occasioned by the demand of the fish farming industry for the control of infectious diseases. Although fish are poikilothermic, aquatic vertebrates, they possess a system of defense mechanism displaying many similarities with those of their mammalian counterparts. Moreover, it is now indisputable that fish are closer to mammals than to any invertebrate taxon [9]. The first line of defense mechanism present in fish is the innate or non-specific mechanism [5].

Objectives of Immunostimulation

The objectives of incorporating immunostimulant source in the diet of fish and other animals are as follows:

i. To promote a greater and more effective sustained immune response to those infectious agents producing subclinical disease without risks of toxicity, carcinogenicity or tissue residues.

ii. To enhance the level and duration of specific immune response, both cell mediated and humoral, following vaccination.

iii. To selectively stimulate the relevant components of the immune system or nonspecific immune mechanism that preferentially confers protection against microorganisms. For example via interferon release, especially for those infectious agents for which no vaccines currently exists and

iv. To maintain immune surveillance at heightened level to ensure early recognition and elimination of neoplastic changes in tissues.

Types of Immunostimulants Used in Aquaculture

  1. Levamisole is an anthelmintic used for treatment of nematodes in man and animals (Synthetic Chemicals): Levamisole is enhancing metabolic and phagocytic activation of neutrophils and increase the number of phagocytes and leucocytes and the level of Lysozyme. In Coho salmon, it increase resistance against Aeromonas salmonisida infection, In carp, it enhance phagocytic activity, myeloperoxidase activity in neutrophils, increase leukocytes number and serum lysozyme levels.
  2. FK-656 (Hepatonoyl-y-glutamyl-(L) mrsodiaminopimely–(D)–alanine is a peptide Related to lactoyl tetra peptide (Synthetic Chemicals). FK-656 has been shown activity against microbial infection. It increases the resistance of Rainbow trout against salmonicida. In Yellow tail, it elevate humoral antibody titers and splenic producing Antibody.
  3. MDP (Muramyl dipeptide) N-acetylmuramyl-L-alanyl-D-Isoglutamine) derived from Mycobacterium (Bacterial derivatives). It activate macrophages, B lymphocytes and alternative pathway of complement [6-19]. MDP increase the phagocytic activities, respiratory burst and migration activities of kidney leucocytes as well as resistance of the fish to salmonicida challenge.
  4. LPS (lipopolysaccharide) is a cell wall component of Gram-negative bacteria (Bacterial derivatives). LPS stimulate B cell
  5. Herbs as Immunostimulant: Natural plant products have been reported as anti-stress, growth promotion, appetite stimulation, tonic, immunostimulation, and to have aphrodisiac and antimicrobial properties in finfish and shrimp larviculture due to the presence of active principles such as alkaloids, flavanoids, pigments, phenolics, terpenoids, steroids and essential oils. The other merits that herbs as immunostimulants are local availability, broad spectrum effect, cost effective, no side effects and biodegradable. [12] fed catfish (Mystus montanus) with dietary Ocimum tenuiflorum, Zingiber officinale and Allium sepa (0.5 g/100 g each) for 45 days and analysed growth, haematological and serum biochemical parameters. Specific growth rate, total erythrocytes, haemoglobin, total leucocytes, total serum protein, glucose, cholesterol, magnesium levels, serum amylase, alkaline phosphatase, SGOT, SGPT and GGT have increased in all herbal supplemented fishes (especially in officinale) than control. Thus concluded that all the three herbs have immunostimulant potential and among the three herbs Zingiber officinale is more potent.

Mode of Action

The mode of action of immunostimulants is to activate the immune systems of organisms, to enhance the immunity level against invading pathogens. The approach is very diverse in nature or may be poorly understood and also depends on the type of immunostimulants, dose, and route of administration, time and period of exposure.

Advantages of Immunostimulants

  1. They are widely and successfully applied to improve fish welfare, health and production [18].
  2. It facilitates function of phagocytic cells, increase their bactericidal activities and stimulate natural killer cells, complement system, lysozyme activity and antibody response in fish and shellfish which confer enhanced protection from infectious diseases [13].
  3. It consider as enhancer to the non-specific immune responses along with the improvement of aquatic environmental quality [19].
  4. Controls fish diseases by enhancing both specific and non-specific defense mechanisms.
  5. Immunostimulants increase the immunocompetency and disease resistance of fish.
  6. Many IS have been developed to improve immunity of domestic animals.
  7. Some immunostimulant enhanced phagocytic activity and myeloperoxidase activity in neutrophils,

Disadvantages of Immunostimulants

  1. They are expensive.
  2. Limited efficiency upon parentally administration [6].
  3. They are not effective against all diseases.
  4. They induce immunosuppression when overdosed [1].

Conclusion

In conclusion, immunostimulants can reduce the losses caused by various diseases in aquaculture; but they may not be effective against all diseases. For the effective use of immunostimulants, the timing, dosages, method of administration and health status of animal need to be taken into consideration. Immunostimulants are substances that control diseases in aquaculture. They enhanced the function of phagocytic cells and increase their bactericidal activities. They also stimulate and complement lysozyme and antibody responses of fish. The effective method of administration of immunostimulants to fish is by injection. Oral and immersion methods have also been observed, but the efficacy of these methods decreases with longterm administration.

References

  1. Ian B, Roy AD (2005) The use of immunostimulants in fish larval Aquaculture. Fish and Shellfish Immunology 19: 457-472.
  2. Maqsood S, Prabjeet S, Munir HS, Khusheebee M (2011) Emerging role of immunostimulants in combating he disease outbreak in aquaculture. International Journal of Aquatic Research 3: 147-163.
  3. Raa J (2016) The use of immunostimulatory substances in fish and shellfish farming. Revision and Fisheries Science 4: 229-288.
  4. Sher J, Font-Llitjós M, Fort J, Zorzano A, Goldfarb DS, et al. (1975) Pathophysiology and treatment of cystinuria. Nature Revised Nephrology 6: 424-434. [crossref]
  5. Sakai M (1999) Current research status of fish immunostimulants. Aquaculture 1:30-80.
  6. Midtlyng PJ (2017) Vaccinated fish welfare: protection versus side effects. Developments and Biological Standards 90: 371-379. [crossref]
  7. Rodriguez A, Cuesta A, Ortuno J; Esteban MA, Meseguer J (2003) Immunostimulant properties of a cell wall-modified whole Saccharomyces cerevisiae strain administered by diet to seabream (Sparus aurata L.). Veterinary Immunology and Immunopathology 96: 183-192. [crossref]
  8. Volman R, Neilsen CU, Brodin B (2008) Basolateral glycylsarcosine (Gly-Sar) transport in Caco-2 cell monolayers is pH dependent. Journal of Pharmacy and Pharmacology 65: 970-979. [crossref]
  9. Manning L (1984) Effects of Chitosan on growth and Serum biochemical parameters of the white shrimp. Freshwater Fisheries 36: 6-8.
  10. Symoens I, Rosenthall M (1977) Levamisole in the modulation of the immune responses: The current experimental and clinical state. Journal of Reticuloendothelial Society 21: 175-221. [crossref]
  11. Oliver G, Evelyn TPT, Lallier T (1985) Immunity to Aeromona salmonicida in Coho salmon (Oncorhync husKisutch) induced by modified Freund,s complete adjuvant: Its non-specific nature and the probable role of macrophages in phenomenon. Developmental & Comparative Immunolgy 9: 419-432. [crossref]
  12. Kitao T, Yashida T, Anderson DP, Blanch A (1987) Immunostimulation of antibodyproducing cells and humoral antibody to fish bacterins by a biological response modifier. Journal of Fish Biology 31: 87-91.
  13. Kodama H Mukamoto N, Baba T, Mule DM (1994) Macrophage-Colony stimulating activity in Rainbow trout (Oncorhychus mykiss) serum. In: Stolen JS, Flecher TC, (EDs.), Modulators of fish immune responses. S0S publications, Fair Haven, NJ 1: 59-66.
  14. Bullock G, Blozer V, Tsukunda S, Summerfelt S (2000) Toxicity of acidification of chitosan for cultured rainbow trout (Oncorhynchus mykiss). Aquaculture 185: 273-280.
  15. Philip R, Sreekumar K, Anas A (2001) Bright Singh IS Immunostimulants–Source, diversity, commercial preparations and mode of application. Nat Workshop on Aquaculture Medicine 74.
  16. Robertsen B, Rorstad G, Engstad R, Raa J (1990) Enhancement of nonspecific disease resistance in Atlantic salmon, Salmo salar L., by a glucan from Saccharomyces cerevisiae cell walls. J Fish Dis 13: 391-400.
  17. Tewary A, Patra BC (2008) Use of Vitamin C as an immunostimulant-effect on growth, nutritional quality, and immune response of Labeo rohita (Ham.). Fish Physiol Biochem 34: 251-259. [crossref]
  18. Villegas JG, Fukada H, Masumoto T, Hosokawa H (2006) Effect of Dietary Immunostimulants on Some Innate Immune Responses and Disease Resistance against Edwardsiella tarda Infection in Japanese Flounder (Paralichthys olivaceus). Aquaculture Sci 54: 153-162.
  19. Wise DJ, Tomasso JR, Gatlin DM, Bai SC, Blazer VS (2011) Effects of dietary selenium and vitamin E on red blood cell peroxidation, glutathione peroxidase activity, and Macrophage Superoxide Anion Production in Channel Catfish. Journal of Aquatic Animal Health 5: 177-182.